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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MAPK8 / JNK1 Antibody (phospho‑Thr183/Tyr185/Thr221/Tyr223) LS‑C16104
JNK1 antibody LS-C16104 is an unconjugated rabbit polyclonal antibody to JNK1 (MAPK8) from human, mouse, rat and other species. Validated for IP and WB.
Antibody
Catalog
Size
Price
LS-C16104-200
200 µg (1 mg/ml)
$590

Popular MAPK8 / JNK1 Products

Anti-MAPK8 / JNK1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3403 concentration 5 ug/ml.
Species: Human, Monkey, Mouse, Rat, Rabbit, Chicken
Applications: IHC, IHC - Paraffin, Western blot
Antibody
Species: Human, Monkey, Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus, Zebrafish, Drosophila
Applications: Western blot, ELISA
Anti-MAPK8 / JNK1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6390 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
NIH/3T3 cell lysate was probed with anti-JNK at 1:200.
Species: Human, Monkey, Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus, Zebrafish, Drosophila
Applications: Western blot, ELISA
Anti-MAPK8 / JNK1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6391 concentration 2.5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Immunoprecipitation, ELISA

Product Description

JNK1 antibody LS-C16104 is an unconjugated rabbit polyclonal antibody to JNK1 (MAPK8) from human, mouse, rat and other species. Validated for IP and WB.
About MAPK8 / JNK1
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. P45983 NM_139049 NP_620637.1

MAPK8 Antibody, JNK Antibody, JNK1 Antibody, JNK1A2 Antibody, JNK-46 Antibody, MAP kinase 8 Antibody, PRKM8 Antibody, SAPK1 Antibody, SAPK1c Antibody, MAPK 8 Antibody, C-Jun N-terminal kinase 1 Antibody, JNK21B1/2 Antibody, JUN N-terminal kinase Antibody


Specifications

Target
Human MAPK8 / JNK1
Host
Rabbit
Reactivity
Human, Mouse, Rat, Chicken, Drosophila, C. elegans (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Protein A purified
Modifications
Unmodified
Applications
  • Western blot (1 µg/ml)
  • Immunoprecipitation (1 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
MAPK8 / JNK1 antibody was raised against synthetic peptide corresponding to aa181-190 [(MM[pT]P[pY]VVTRY-C)] of human/mouse/rat JNK1 (MAPK 8) and human/mouse/rat JNK2 (MAPK 9). Sequence also matches aa219-229 of human/mouse/rat JNK3.
Epitope
pThr183/Tyr185/Thr221/Tyr223
Specificity
Recognizes phosphorylated JNK, Mr 46kD and 55kD. Species cross-reactivity: Human, rat, mouse. Expected to cross-react with Drosophila, C. elegans and chicken based on sequence homology.
Usage
Suitable for use in Immunoprecipitation/Western Blot. Immunoprecipitation/Western Blot: 1 ug/ml. Anti-pan JNK/SAPK1 was used to Immunoprecipitate JNK from lysates of ultraviolet light-treated RAW 264 macrophage. Phosphorylated JNK (T183/Y185) was detected. Phosphorylated JNK was not detected in non-treated lysates.
Presentation
0.1 M Tris-Glycine, pH 7.4, 0.15 M NaCl, 0.05% Sodium Azide, 30% Glycerol
Storage
Store at 4°C or -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/19/2018

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