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Anti-MAP3K8 / TPL2 Antibody (Pro284) LS-C175974

Catalog Size Price
LS-C175974-100 100 µl Unavailable

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Rabbit Polyclonal to Human MAP3K8 / TPL2
Human, Mouse, Rat
IHC - Paraffin, Immunofluorescence, Western blot


Human MAP3K8 / TPL2
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Immunoaffinity purified


  • IHC - Paraffin
  • Immunofluorescence
  • Western blot

Specificity and Use

MAP3K8 / TPL2 antibody was raised against synthetic peptide around Pro284 of human COT
Human COT


PBS, pH 7.2, 0.05% sodium azide
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only.

About MAP3K8 / TPL2

P41279 NM_005204 NP_005195.2

MAP3K8 Antibody, C-COT Antibody, Cancer Osaka thyroid oncogene Antibody, COT Antibody, Ewing sarcoma transformant Antibody, EST Antibody, MEKK8 Antibody, Proto-oncogene c-Cot Antibody, TPL2 Antibody, Tumor progression locus 2 Antibody, Protein kinase cot Antibody, Tpl-2 Antibody, ESTF Antibody

Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production.


IHC of COT (P284) pAb in paraffin-embedded human brain tissue.

Western blot

Western blot
Western blot of COT (P284) pAb in extracts from 293 treated with LPS 100ng/ml 30' cells.

Requested From: 
Date Requested: 6/22/2017

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