MAP3K5 / ASK1

mitogen-activated protein kinase kinase kinase 5

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).

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Products

Antibodies (102)

ELISA Kits (16)

Proteins (6)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (2)

Over-Expression Lysate (2)

Primary (102)

Recombinant (4)

Sandwich (10)

Sandwich CLIA (1)

Target

MAP3K5 / ASK1 (124)

Reactivity

Human (108)

Mouse (50)

Rat (22)

Bovine (2)

Chicken (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Application

IHC (53)

IHC-Fr (2)

IHC-P (18)

WB (92)

Flo (3)

ELISA (36)

ICC (3)

IF (9)

IP (2)

Peptide-ELISA (7)

Host

rabbit (98)

mouse (4)

Product Group

IHCPlus (3)

Isotype

IgG (62)

IgG1 (3)

IgG2b,k (1)

Clonality

monoclonal mc (4)

polyclonal pc (98)

Clone

20000 (1)

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5C4 (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (5)

96-Well Strip Plate (10)

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FITC Conjugated (7)

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Epitope

Ser966 (8)

aa681-936 (8)

aa693-933 (8)

pSer966 (8)

aa1175-1203 (7)

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N-Terminus (3)

20-100 aa (2)

910-990 aa (2)

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Glu960 (1)

Internal (1)

Val972 (1)

aa1198-1216 (1)

aa280 (1)

aa49-98 (1)

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Publications

No (123)

Yes (1)

Sample Type

Adherent Cell Cultures (3)

Cell Lysates (1)

Plasma (6)

Serum (6)

Tissue Homogenates (3)

Tag

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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IHC-plus™ MAP3K5 / ASK1 Antibody LS-B3205

(4.0) Rating

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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IHC-plus™ MAP3K5 / ASK1 Antibody LS-B3206

(4.0) Rating

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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MAP3K5 / ASK1 Antibody (20-100 aa) LS-C382174

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal (20-100 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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MAP3K5 / ASK1 Antibody (phospho-Ser83) LS-C18846

(4.0) Rating

(1) Publication(s)

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal (pSer83) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µg/$567

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Mouse/Human/Rat Phospho-MAP3K5 / ASK1 (Ser966) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1451

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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MAP3K5 / ASK1 Antibody (N-Terminus) LS-C368417

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$263; 100 µl/$315; 200 µl/$379

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MAP3K5 / ASK1 Antibody (clone 5C4) LS-C197672

Antibody:

MAP3K5 / ASK1 Mouse anti-Human Monoclonal (5C4) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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MAP3K5 / ASK1 Antibody (phospho-Ser966) LS-C177874

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal (pSer966) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$328; 100 µl/$419

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MAP3K5 / ASK1 Antibody LS-C812505

Antibody:

MAP3K5 / ASK1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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MAP3K5 / ASK1 Antibody (clone 20000) LS-C758667

Antibody:

MAP3K5 / ASK1 Mouse anti-Human Monoclonal (20000) Antibody

Reactivity:

Human

Applications:

Flo, ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$518

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MAP3K5 / ASK1 Antibody (clone 2E4) LS-C169375

Antibody:

MAP3K5 / ASK1 Mouse anti-Human Monoclonal (2E4) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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IHC-plus™ MAP3K5 / ASK1 Antibody (aa49-98) LS-B7565

(4.0) Rating

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal (aa49-98) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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MAP3K5 / ASK1 Antibody LS-C271

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

Unconjugated

Price:

100 µg/$448

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MAP3K5 / ASK1 Antibody (phospho-Ser966) LS-C801226

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal (pSer966) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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MAP3K5 / ASK1 Antibody (phospho-Ser83) LS-C801224

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal (pSer83) Antibody

Reactivity:

Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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MAP3K5 / ASK1 Antibody LS-C801664

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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MAP3K5 / ASK1 Antibody LS-C499284

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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Mouse MAP3K5 / ASK1 Protein (Recombinant His-T7) (aa693-933) - LS-G13707

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.8 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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MAP3K5 / ASK1 Antibody (aa1175-1203) LS-C164455

Antibody:

MAP3K5 / ASK1 Rabbit anti-Mouse Polyclonal (aa1175-1203) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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MAP3K5 / ASK1 Antibody (aa1175-1203) LS-C329813

Antibody:

MAP3K5 / ASK1 Rabbit anti-Mouse Polyclonal (aa1175-1203) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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MAP3K5 / ASK1 Antibody (aa1198-1216) LS-C148204

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal (aa1198-1216) Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$386

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MAP3K5 / ASK1 Antibody (phospho-Ser83) LS-C117292

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal (pSer83) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

MAP3K5 / ASK1 Antibody (phospho-Ser966) LS-C117293

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal (pSer966) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

MAP3K5 / ASK1 Antibody LS-C122699

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$489

Select

MAP3K5 / ASK1 Antibody LS-C122698

Antibody:

MAP3K5 / ASK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$489

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