MAP3K4 / MEKK4

mitogen-activated protein kinase kinase kinase 4

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described.

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Products

Antibodies (22)

Proteins (3)

Type

Over-Expression Lysate (2)

Primary (22)

Recombinant (1)

Target

MAP3K4 / MEKK4 (25)

Reactivity

Human (22)

Mouse (9)

Rat (2)

Application

IHC (16)

IHC-P (6)

WB (14)

ELISA (12)

IF (1)

IP (1)

Peptide-ELISA (2)

Host

rabbit (20)

mouse (2)

Isotype

IgG (16)

IgG1,k (2)

Clonality

monoclonal mc (2)

polyclonal pc (20)

Clone

4F10 (1)

6C6 (1)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (14)

Epitope

aa1067-1097 (7)

1250-1330 aa, C-terminal (1)

C-Terminus (1)

aa1281-1330 (1)

aa75-125 (1)

Publications

No (25)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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MAP3K4 / MEKK4 Antibody (aa75-125) LS-C290918

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (aa75-125) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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MAP3K4 / MEKK4 Antibody (clone 4F10) LS-C133320

Antibody:

MAP3K4 / MEKK4 Mouse anti-Human Monoclonal (4F10) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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MAP3K4 / MEKK4 Antibody (clone 6C6) LS-C133319

Antibody:

MAP3K4 / MEKK4 Mouse anti-Human Monoclonal (6C6) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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MAP3K4 / MEKK4 Antibody LS-C666631

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$341

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MAP3K4 / MEKK4 Antibody (aa1067-1097) LS-C329827

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (aa1067-1097) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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MAP3K4 / MEKK4 Antibody (aa1067-1097, Biotin) LS-C262996

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (aa1067-1097) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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MAP3K4 / MEKK4 Antibody (aa1067-1097, FITC) LS-C262997

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (aa1067-1097) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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MAP3K4 / MEKK4 Antibody (aa1067-1097, APC) LS-C262995

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (aa1067-1097) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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MAP3K4 / MEKK4 Antibody (aa1067-1097, PE) LS-C262999

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (aa1067-1097) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

MAP3K4 / MEKK4 Antibody (aa1067-1097, Azide-free, HRP) LS-C262998

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (aa1067-1097) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

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MAP3K4 / MEKK4 Antibody LS-C671538

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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MAP3K4 / MEKK4 Antibody (HRP) LS-C671539

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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MAP3K4 / MEKK4 Antibody (Biotin) LS-C671542

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

MAP3K4 / MEKK4 Antibody (FITC) LS-C671540

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

MAP3K4 / MEKK4 Antibody LS-C800668

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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MAP3K4 / MEKK4 Antibody (aa1067-1097) LS-C164134

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (aa1067-1097) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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MAP3K4 / MEKK4 Antibody (C-Terminus) LS-C356168

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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MAP3K4 / MEKK4 Antibody (1250-1330 aa, C-terminal) LS-C384482

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (1250-1330 aa, C-terminal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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MAP3K4 / MEKK4 Antibody (aa1281-1330) LS-C119358

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal (aa1281-1330) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

MAP3K4 / MEKK4 Antibody LS-C823340

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

MAP3K4 / MEKK4 Antibody LS-C416327

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

MAP3K4 / MEKK4 Antibody LS-C412071

Antibody:

MAP3K4 / MEKK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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MAP3K4 / MEKK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115649

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

181.6 kDa

Price:

100 µg/$710

Select

Human MAP3K4 / MEKK4 Protein (Recombinant GST, N-terminus) (aa1201-1300) - LS-G59220

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human MAP3K4 / MEKK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80039

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

181.6 kDa

Price:

20 µg/$215

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