Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
MAP3K14, also known as NIK for NF-kappaB-inducing kinase, is a MAP3K type protein kinase. NIK/MAP3K14 is a member of a NF-kappaB-inducing signalling cascade common to receptors of the tumor-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. The protein has been shown to mediate TNF activation of NF-kappaB by associating with the adapter protein TRAF2. NIK/MAP3K14 (-/-) mice lack lymph nodes and have defective development of Peyer patches.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
The anti-NIK antibody is used in Western blot to detect NIK in 293 cell lysate (Lane 1) and rat testis tissue lysate (Lane 2).
Requested From: United States
Date Requested: 12/7/2016