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MAP2

microtubule-associated protein 2

MAP2 is a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.

Gene Name:	microtubule-associated protein 2
Synonyms:	MAP2, MAP2C, MAP-2, MAP2A, MAP2B
Target Sequences:	NM_002374 NP_002365.3 P11137

Publications (21)

Synaptic and nonsynaptic localization of protocadherin-gammaC5 in the rat brain. Li Y, Serwanski DR, Miralles CP, Fiondella CG, Loturco JJ, Rubio ME, De Blas AL. The Journal of comparative neurology. 2010 518:3439-63. [PubMed:20589908] [PMC:PMC3209968]

A hybrid nanofiber matrix to control the survival and maturation of brain neurons. Sur S, Pashuck ET, Guler MO, Ito M, Stupp SI, Launey T. Biomaterials. 2012 33:545-55. [PubMed:22018390] [PMC:PMC3210375]

Automated quantification of synapses by fluorescence microscopy. Schtzle P, Wuttke R, Ziegler U, Sonderegger P. Journal of neuroscience methods. 2012 204:144-9. [PubMed:22108140]

Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-. Scuderi C, Valenza M, Stecca C, Esposito G, Carrat MR, Steardo L. Journal of neuroinflammation. 2012 9:49. (ICC; Rat) [PubMed:22405189] [PMC:PMC3315437]

NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3. Chao HW, Lai YT, Lu YL, Lin CL, Mai W, Huang YS. Nucleic acids research. 2012 40:8484-98. (ICC; Mouse, Rat) [PubMed:22730302] [PMC:PMC3458550]

Action potential-independent and pharmacologically unique vesicular serotonin release from dendrites. Colgan LA, Cavolo SL, Commons KG, Levitan ES. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:15737-46. (ICC, IHC; Rat) [PubMed:23136413] [PMC:PMC3505755]

The complex PrP(c)-Fyn couples human oligomeric A with pathological tau changes in Alzheimer's disease. Larson M, Sherman MA, Amar F, Nuvolone M, Schneider JA, Bennett DA, Aguzzi A, Lesn SE. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:16857-71a. (ICC, IHC; Human) [PubMed:23175838] [PMC:PMC3568961]

Neurobeachin regulates neurotransmitter receptor trafficking to synapses. Nair R, Lauks J, Jung S, Cooke NE, de Wit H, Brose N, Kilimann MW, Verhage M, Rhee J. The Journal of cell biology. 2013 200:61-80. (ICC, IHC; Mouse) [PubMed:23277425] [PMC:PMC3542797]

Frequent infection of cortical neurons by JC virus in patients with progressive multifocal leukoencephalopathy. Wüthrich C, Koralnik IJ. Journal of neuropathology and experimental neurology. 2012 71:54-65. (IHC; Human) [Full Text Article] [PubMed:22157619] [PMC:PMC3246306] Related Antibodies: LS-B290.

Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment. Tucsek Z, Noa Valcarcel-Ares M, Tarantini S, Yabluchanskiy A, Fülöp G, Gautam T, Orock A, Csiszar A, Deak F, Ungvari Z. GeroScience. 2017 (ICC, WB; Human, Rat) [Full Text Article] [PubMed:28664509] [PMC:PMC5636782] Related Antibodies: LS-B3439.

JC virus encephalopathy is associated with a novel agnoprotein-deletion JCV variant. Dang X, Wüthrich C, Gordon J, Sawa H, Koralnik IJ. PloS one. 2012 7:e35793. (IHC-P; Human) [Full Text Article] [PubMed:22536439] Related Antibodies: LS-B290.

Evolution of Osteocrin as an activity-regulated factor in the primate brain. Ataman B, Boulting GL, Harmin DA, Yang MG, Baker-Salisbury M, Yap EL, Malik AN, Mei K, Rubin AA, Spiegel I, Durresi E, Sharma N, Hu LS, Pletikos M, Griffith EC, Partlow JN, Stevens CR, Adli M, Chahrour M, Sestan N, Walsh CA, Berezovskii VK, Livingstone MS, Greenberg ME. Nature. 2016 November;539:242-247. (Bovine) [Full Text Article] [PubMed:27830782] [PMC:PMC5499253] Related Antibodies: LS-C61805.

Natalizumab-associated progressive multifocal leukoencephalopathy in a patient with multiple sclerosis: a postmortem study. Wüthrich C, Popescu BF, Gheuens S, Marvi M, Ziman R, Denq SP, Tham M, Norton E, Parisi JE, Dang X, Lucchinetti CF, Koralnik IJ. Journal of neuropathology and experimental neurology. 2013 November;72:1043-51. [Full Text Article] [PubMed:24128680] [PMC:PMC4465443] Related Antibodies: LS-B290.

Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons. Carlos G Sanchez, Christopher M Acker, Audrey Gray, Malini Varadarajan, Cheng Song, Nadire R Cochran, Steven Paula, Alicia Lindeman, Shaojian An, Gregory McAllister, John Alford, John Reece-Hoyes, Carsten Russ, Lucas Craig, Ketthsy Capre, Christian Doherty, Gregory R Hoffman, Sarah J Luchansky, Manuela Polydoro, Ricardo Dolmetsch, Fiona Elwood. Communications biology. 2021 June;4:736. [Full Text Article] [PubMed:34127790] [PMC:PMC8203616] Related Antibodies: LS-C61805.

Lack of Major Histocompatibility Complex Class I Upregulation and Restrictive Infection by JC Virus Hamper Detection of Neurons by T Lymphocytes in the Central Nervous System. Christian Wüthrich, Stephanie Batson, Igor J Koralnik. Journal of neuropathology and experimental neurology. 2015 August;74:791-803. [Full Text Article] [PubMed:26115192] [PMC:PMC4506730] Related Antibodies: LS-B290.

Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms. Maria Masnata, Giacomo Sciacca, Alexander Maxan, Luc Bousset, Hélèna L Denis, Florian Lauruol, Linda David, Martine Saint-Pierre, Jeffrey H Kordower, Ronald Melki, Melanie Alpaugh, Francesca Cicchetti. Acta neuropathologica. 2019 June;137:981-1001. [Full Text Article] [PubMed:30788585] [PMC:PMC6531424] Related Antibodies: LS-B290.

JC Virus Infects Neurons and Glial Cells in the Hippocampus. Christian Wüthrich, Stephanie Batson, Matthew P Anderson, Lon R White, Igor J Koralnik. Journal of neuropathology and experimental neurology. 2016 Aug;75:712-717. [Full Text Article] [PubMed:27297673] [PMC:PMC5909865] Related Antibodies: LS-B290.

Activity-dependent regulome of human GABAergic neurons reveals new patterns of gene regulation and neurological disease heritability. Gabriella L Boulting #, Ershela Durresi # , Bulent Ataman #, Maxwell A Sherman # , Kevin Mei, David A Harmin, Ava C Carter, Daniel R Hochbaum, Adam J Granger, Jesse M Engreitz, Sinisa Hrvatin, Michael R Blanchard , Marty G Yang, Eric C Griffith, Michael E Greenberg. Nature neuroscience. 2021 Mar;;24:437-448. [Full Text Article] [PubMed:33542524] [PMC:PMC7933108] Related Antibodies: LS-C61805.

Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism. Lucas Cheadle, Samuel A Rivera, Jasper S Phelps, Katelin A Ennis, Beth Stevens, Linda C Burkly, Wei-Chung Allen Lee, Michael E Greenberg. Neuron. 2020 November;108:451-468e9. [Full Text Article] [PubMed:32931754] [PMC:PMC7666095] Related Antibodies: LS-C61805.

INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury. Barbara Calabrese, Steven L Jones, Yoko Shiraishi-Yamaguchi, Michael Lingelbach, Uri Manor, Tatyana M Svitkina, Henry N Higgs, Andy Y Shih, Shelley Halpain. Nature communications. 2022 October;13:6037. [Full Text Article] [PubMed:36229429] [PMC:PMC9558009] Related Antibodies: LS-B290.

Activity-dependent dendritic spine shrinkage and growth involve downregulation of cofilin via distinct mechanisms. Calabrese B, Saffin JM, Halpain S. PloS one. 2014 9:e94787. [Full Text Article] [PubMed:24740405] [PMC:PMC3989342] Related Antibodies: LS-B290.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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