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Anti-MALT1 Antibody (aa43-57) IHC-plus™ LS-B2051

Note: This antibody replaces LS-C739
Catalog Size Price
LS-B2051-50 50 µg (0.5 mg/ml) Unavailable

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Anti-MALT1 Antibody (aa270-350) LS-C384416
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100% Guaranteed
Rabbit Polyclonal (IgG) to Human MALT1
Human
IHC - Paraffin, Western blot
Unconjugated

Details

Human MALT1
Rabbit
Human (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Protein G purified
Unmodified

Applications

  • IHC - Paraffin (10 µg/ml)
  • Western blot (0.5 - 2 µg/ml)

Specificity and Use

MALT1 antibody was raised against a synthetic peptide corresponding to amino acids 43-57 (ELLDQAPEGRGWRRL) of human MALT1 (GenBank No. NP_776216.1). The immunogen sequence is 100% conserved between Malt1 isoforms a and b. Percent identity by BLAST analysis: Human (100%); Monkey (93%); Chimpanzee, Gorilla, Orangutan, Gibbon, Elephant (87%); Galago, Marmoset, Bovine, Cat (80%); Mouse, Rat (73%).
aa43-57
A synthetic peptide corresponding to amino acids 43-57 (ELLDQAPEGRGWRRL) of human MALT1 (GenBank No. NP_776216.1) was used as immunogen. The immunogen sequence is 100% conserved between Malt1 isoforms a and b.
Immunohistochemistry: LS-B2051 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2051 was determined to be 10 ug/ml.

Packaging

PBS, 0.2% gelatin, 0.05% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

About MALT1

Q9UDY8 NM_006785 NP_006776.1

MALT1 Antibody, Caspase-like protein Antibody, MLT Antibody, MLT1 Antibody, Paracaspase Antibody, MALT associated translocation Antibody

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.

Immunohistochemistry

Immunohistochemistry
Anti-MALT1 antibody IHC of human colon-lymphoid follicle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2051 concentration 10 ug/ml.

Western blot

Western blot
Western blot ofumALT1 in Jurkat cell lysate using antibody at 0.5 ug/ml.

Requested From: 
Date Requested: 10/19/2017

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