MAGOH

mago-nashi homolog, proliferation-associated (Drosophila)

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.

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Products

Antibodies (21)

Proteins (8)

Type

Over-Expression Lysate (2)

Primary (21)

Recombinant (6)

Target

MAGOH (29)

Reactivity

Human (21)

Mouse (5)

Rat (5)

Bat (4)

Bovine (4)

Chicken (4)

Chimpanzee (3)

Dog (4)

Drosophila (4)

Gibbon (3)

Guinea pig (3)

Hamster (4)

Horse (4)

Insect (1)

Monkey (5)

Pig (4)

Rabbit (4)

Xenopus (4)

Zebrafish (4)

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Application

IHC (10)

IHC-P (2)

WB (21)

ELISA (11)

IF (1)

IP (4)

Peptide-ELISA (2)

Host

rabbit (18)

mouse (2)

goat (1)

Isotype

IgG (11)

IgG1 (1)

IgG1,k (1)

Clonality

monoclonal mc (2)

polyclonal pc (19)

Clone

6E11 (1)

Format

APC Conjugated (1)

Azide-free (2)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (13)

Epitope

aa46-74 (7)

aa31-80 (4)

aa1-111 (1)

aa98-109 (1)

Publications

No (29)

Tag

GST (1)

GST, N-terminus (2)

His (2)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (7)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

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MAGOH Antibody (aa46-74) LS-C163974

Antibody:

MAGOH Rabbit anti-Human Polyclonal (aa46-74) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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MAGOH Antibody LS-C676014

Antibody:

MAGOH Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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MAGOH Antibody LS-C802782

Antibody:

MAGOH Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human, Monkey

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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MAGOH Antibody LS-C666612

Antibody:

MAGOH Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$351

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MAGOH Antibody (aa46-74) LS-C322805

Antibody:

MAGOH Rabbit anti-Human Polyclonal (aa46-74) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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MAGOH Antibody (aa46-74, Biotin) LS-C223130

Antibody:

MAGOH Rabbit anti-Human Polyclonal (aa46-74) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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MAGOH Antibody (aa46-74, FITC) LS-C223131

Antibody:

MAGOH Rabbit anti-Human Polyclonal (aa46-74) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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MAGOH Antibody (aa46-74, APC) LS-C223129

Antibody:

MAGOH Rabbit anti-Human Polyclonal (aa46-74) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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MAGOH Antibody (aa46-74, PE) LS-C223133

Antibody:

MAGOH Rabbit anti-Human Polyclonal (aa46-74) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

MAGOH Antibody (aa46-74, Azide-free, HRP) LS-C223132

Antibody:

MAGOH Rabbit anti-Human Polyclonal (aa46-74) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

MAGOH Antibody LS-C676017

Antibody:

MAGOH Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

MAGOH Antibody (clone 6E11) LS-C139276

Antibody:

MAGOH Mouse anti-Human Monoclonal (6E11) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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MAGOH Antibody LS-C488216

Antibody:

MAGOH Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µl/$412

Select

MAGOH Antibody (aa98-109) LS-C55081

Antibody:

MAGOH Goat anti-Human Polyclonal (aa98-109) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Insect, Drosophila, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

MAGOH Antibody (aa1-111, Azide-free) LS-C327807

Antibody:

MAGOH Mouse anti-Human Monoclonal (aa1-111) (Azide-free) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Azide-free

Price:

100 µg/$705

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MAGOH Antibody LS-C767991

Antibody:

MAGOH Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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MAGOH Antibody (aa31-80) LS-C135763

Antibody:

MAGOH Rabbit anti-Human Polyclonal (aa31-80) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

MAGOH Antibody (aa31-80, HRP) LS-C467356

Antibody:

MAGOH Rabbit anti-Human Polyclonal (aa31-80) (HRP) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Drosophila, Rat, Hamster, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

MAGOH Antibody (aa31-80, Biotin) LS-C467353

Antibody:

MAGOH Rabbit anti-Human Polyclonal (aa31-80) (Biotin) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Drosophila, Rat, Hamster, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

MAGOH Antibody (aa31-80, FITC) LS-C467354

Antibody:

MAGOH Rabbit anti-Human Polyclonal (aa31-80) (FITC) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Drosophila, Rat, Hamster, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

MAGOH Antibody LS-C668602

Antibody:

MAGOH Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

Select

Human MAGOH Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G59176

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human MAGOH Protein (Recombinant GST, N-terminus) (aa1-146) - LS-G56389

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

Select

Human MAGOH Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87603

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17 kDa

Price:

20 µg/$150

Select

Human MAGOH Protein (Recombinant His) (Met1-Ile146) - LS-G97670

Source:

E. coli

Tag:

His

Molecular Weight:

18 kDa

Price:

100 µg/$721

Viewing 1-25 of 29 product results

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