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MAGEA3
melanoma antigen family A, 3
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
| Gene Name: | melanoma antigen family A, 3 |
| Synonyms: | MAGEA3, Antigen MZ2-D, Cancer/testis antigen 1.3, CT1.3, HYPD, MAGE-3 antigen, Melanoma-associated antigen 3, HIP8, MAGE3, Melanoma antigen family A, 3 |
| Target Sequences: | U03735 AAA17446.1 P43357 |
Publications (4)
1
MAGE-C1/CT7 is the dominant cancer-testis antigen targeted by humoral immune responses in patients with multiple myeloma. Curioni-Fontecedro A, Knights AJ, Tinguely M, Nuber N, Schneider C, Thomson CW, von Boehmer L, Bossart W, Pahlich S, Gehring H, Moch H, Renner C, Knuth A, Zippelius A. Leukemia. 2008 22:1646-8.
[PubMed:18323799]
Related Antibodies: LS-C99934.
2
CD8+ TIL recruitment may revert the association of MAGE A3 with aggressive features in thyroid tumors. Martins MB, Marcello MA, Batista Fde A, Cunha LL, Morari EC, Soares FA, Vassallo J, Ward LS. Journal of immunology research. 2014 2014:921864. (IHC; Human)
[Full Text Article]
[PubMed:25825704]
[PMC:PMC4235601]
3
Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma. Kenji Murata , Munehide Nakatsugawa , Muhammed A Rahman, Linh T Nguyen, Douglas G Millar, David T Mulder, Kenji Sugata, Hiroshi Saijo, Yukiko Matsunaga, Yuki Kagoya, Tingxi Guo, Mark Anczurowski, Chung-Hsi Wang, Brian D Burt, Dalam Ly, Kayoko Saso, Alexandra Easson, David P Goldstein, Michael Reedijk, Danny Ghazarian, Trevor J Pugh, Marcus O Butler, Tak W Mak, Pamela S Ohashi, Naoto Hirano. eLife. 2020 Apr;9:e53244. [Full Text Article]
[PubMed:32314731]
[PMC:PMC7234812]
Related Antibodies: LS-C99934.
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MAGEA3 Rabbit anti-Human Polyclonal (aa216-265) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
MAGEA3 Rabbit anti-Human Polyclonal (aa216-265) (FITC) Antibody
Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
MAGEA3 Mouse anti-Human Monoclonal (4E2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
MAGEA3 Mouse anti-Human Monoclonal (1G9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
MAGEA3 Rabbit anti-Human Polyclonal (aa283-314) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
E. coli
6His, N-terminus
50 µg/$411; 250 µg/$985; 10 µg/$276
MAGEA3 Mouse anti-Human Monoclonal (OTI1A10) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAGEA3 Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
100 µg/$842
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MAGEA3 Mouse anti-Human Monoclonal (1A9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
MAGEA3 Mouse anti-Human Monoclonal (2F10) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
MAGEA3 Mouse anti-Human Monoclonal (1H1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
MAGEA3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MAGEA3 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$361
MAGEA3 Rabbit anti-Human Polyclonal (aa283-314) Antibody
Human
Flo, IHC, WB
Unconjugated
200 µl/$734
MAGEA3 Rabbit anti-Human Polyclonal (aa283-314) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
MAGEA3 Rabbit anti-Human Polyclonal (aa283-314) (FITC) Antibody
Human
Flo, IHC, WB
FITC Conjugated
200 µl/$952
MAGEA3 Rabbit anti-Human Polyclonal (aa283-314) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
MAGEA3 Rabbit anti-Human Polyclonal (aa283-314) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
MAGEA3 Rabbit anti-Human Polyclonal (aa283-314) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
MAGEA3 Mouse anti-Human Monoclonal (Carrier-free) (2F10) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MAGEA3 Mouse anti-Human Monoclonal (Carrier-free) (1A9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MAGEA3 Mouse anti-Human Monoclonal (Carrier-free) (1H1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MAGEA3 Mouse anti-Human Monoclonal (OTI3B2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAGEA3 Mouse anti-Human Monoclonal (Carrier-free) (1G9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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product results
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