Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone YTH8.18] (IgG2b) to Human Macrophages and Neutrophils
IHC - Frozen, Flow Cytometry
Human Macrophages and Neutrophils
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [YTH8.18]
Ammonium sulfate precipitation
IHC - Frozen (1:20)
Specificity and Use
Human peripheral blood mononuclear cells.
Recognizes all tissue macrophages, binding to a cytoplasmic epitope. In peripheral blood the antibody stains all granulocytes and around 50% of monocytes. No staining of osteoclasts or Langerhans cells is seen.