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MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).
Gene Name: | metastasis associated in colon cancer 1 |
Synonyms: | MACC1, 7A5, Putative binding protein 7a5, SH3BP4L |
Target Sequences: | Q6ZN28 Q6ZN28 |
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