Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 1A2E3] (IgG1) to Human LY96 / MD2 / MD-2
IHC - Paraffin, Western blot, ELISA
Mouse Monoclonal [clone 4H1] (IgG2b) to Human LY96 / MD2 / MD-2
Flow Cytometry (applications tested for the base form of this product only)
Human LY96 / MD2 / MD-2
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [4H1]
Also available conjugated with FITC.
(applications tested for the base form of this product only)
Specificity and Use
LY96 / MD2 / MD-2 antibody was raised against tLR4/MD-2 expressing CHO cells/ chimeric TLR4/MD-2 fusion protein
Human LY96 / MD-2
For flow cytometry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS.