Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG2a) to Human Lung Cancer-Associated Antigen (Cluster 1)
IHC - Frozen, Western blot
Human Lung Cancer-Associated Antigen (Cluster 1)
Human (tested or 100% immunogen sequence identity)
Tissue culture supernatant
IHC - Frozen
Specificity and Use
Isolated from small cell lung carcinoma-derived cell line.
Reactive with lung cancer-associated antigen (cluster 1). Reacts with membrane-associated proteins of 120kD, 125kD and 145kD in normal and malignant tissue, including a subgroup of SCLC. Lack of reactivity with other markers within this SCLC subgroup correlates with a bad response to chemotherapy. Recommended for Brain/adrenal gland. Species cross-reactivity: Human.
Suitable for use in Western Blot and Immunohistochemistry (frozen tissue). Immunohistochemistry: 1:5-1:10; Incubation Time 1 hr at room temperature.