Human LTA / TNF Beta

Rabbit

Human, Rat (tested or 100% immunogen sequence identity)

Mouse, Hamster (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide from the middle region of human TNF beta (KQNSLLWRANTDRAFL, aa73-88 of UniProt P01374). Percent identity by BLAST analysis: Human, Rat (100%); Mouse, Hamster (94%); Ferret, Cat, Horse, Dog (88%); Sheep, Bovine, Rabbit, Zebu (81%).

aa73-88

Human LTA / TNF Beta

• Western blot (0.5 - 1 µg/ml)

Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them. Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs. Nedwin et al. (1985) found that TNFA and TNFB are closely linked on chromosome 6. Study of hybrid cells made with rearranged human chromosome 6 showed that both TNFA and TNFB map to the 6p23-q12 segment.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P01374 NCBI: NM_000595 NP_000586.2