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LRP5
low density lipoprotein receptor-related protein 5
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
| Gene Name: | low density lipoprotein receptor-related protein 5 |
| Synonyms: | LRP5, EVR1, Exudative vitreoretinopathy 1, LRP7, OPTA1, OPPG, OPS, LR3, LRP-5, VBCH2, BMND1, EVR4 |
| Target Sequences: | NM_002335 NP_002326.2 O75197 |
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LRP5 Rabbit anti-Human Polyclonal (aa1538-1567) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
E. coli
His, N-Terminal
32.1 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
LRP5 Mouse anti-Human Monoclonal (aa41-130) (1E9) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
LRP5 Rabbit anti-Human Monoclonal (C-Terminus) (D80F2) Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
100 µl/$688
LRP5 Rabbit anti-Human Polyclonal (aa1201-1215) Antibody
Rabbit, Mouse, Rat, Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
LRP5 Mouse anti-Human Monoclonal (aa1422-1615) (2B11) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
LRP5 Rabbit anti-Human Polyclonal (aa1538-1567) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
LRP5 Rabbit anti-Human Polyclonal (aa1538-1567) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
LRP5 Rabbit anti-Human Polyclonal (aa1538-1567) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
LRP5 Rabbit anti-Human Polyclonal (aa1538-1567) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
LRP5 Rabbit anti-Human Polyclonal (aa1538-1567) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
LRP5 Rabbit anti-Human Polyclonal (aa1538-1567) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
LRP5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
LRP5 Rabbit anti-Human Polyclonal (aa1000-1250) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
LRP5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
IF, WB
Unconjugated
50 µg/$540; 100 µg/$848
LRP5 Goat anti-Human Polyclonal (aa1178-1189) Antibody
Mouse, Rat, Hamster, Horse, Human, Monkey
IHC, Peptide-ELISA, WB
Unconjugated
100 µg/$503
LRP5 Mouse anti-Human Monoclonal (2B11) Antibody
Human
Flo, WB
Unconjugated
100 µg/$503
LRP5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
LRP5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
LRP5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
LRP5 Rabbit anti-Human Polyclonal (aa1163-1190) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
LRP5 Rabbit anti-Mouse Polyclonal (aa1163-1190) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
LRP5 Rabbit anti-Mouse Polyclonal (aa1163-1190) (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
LRP5 Rabbit anti-Mouse Polyclonal (aa1163-1190) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
LRP5 Rabbit anti-Mouse Polyclonal (aa1163-1190) (Azide-free) (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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