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Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology.
Gene Name: | lysophosphatidylcholine acyltransferase 1 |
Synonyms: | LPCAT1, Acyltransferase like 2, Acyltransferase-like 2, AYTL2, Lpcat, Lyso-PAF acetyltransferase, PFAAP3, LPC acyltransferase 1, LPCAT-1, LysoPAFAT, LysoPC acyltransferase 1, Regulated by phosphonoformate |
Target Sequences: | NM_024830 NP_079106.3 Q8NF37 |
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