Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 9G2] (IgG1) to Human LOX / Lysyl Oxidase
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Human, Monkey, Mouse, Bat, Rabbit
IHC, IHC - Frozen, Western blot, Immunoprecipitation
Human LOX / Lysyl Oxidase
Human, Monkey, Mouse, Bat, Rabbit (tested or 100% immunogen sequence identity)
Rat, Bovine, Dog, Horse, Pig (at least 90% immunogen sequence identity)
IHC - Frozen
Western blot (1:250 - 1:1000)
IHC - Paraffin
Specificity and Use
Amino acids 305-320 (DLLDANTQRRVAEGHK)of human LOX protein were used as the immunogen. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Bat, Rabbit (100%); Rat, Dog, Bovine, Elephant, Panda, Horse, Pig, Opossum (94%); Xenopus, Zebrafish (88%); Turkey, Platypus (81%).
Lysyl Oxidase / LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I).