Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone JOL2] (IgG1) to Human LMNA / Lamin A+C
IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry
Mouse Monoclonal (IgG1) to Xenopus LMNA / Lamin A+C
Xenopus, Human, Mouse, Rat, Bovine
IHC, Immunofluorescence, Western blot
Xenopus LMNA / Lamin A+C
Xenopus, Human, Mouse, Rat, Bovine (tested or 100% immunogen sequence identity)
Protein A purified
Specificity and Use
Nuclear pore complex-lamina fraction of Xenopus laevis (XLKE-A6 cells).
Decorates the karyoskeleton, i. e. the intermediate filament equivalent of the nucleus. Polypeptide (s) Reacting: Lamin isotypes of Mr 60-75kD. Species cross-reactivity: Xenopus laevis LA, LI, LIII Bovine LA, C Mouse n. d. Rat - Human LA, C Trout LA, LI, LII Rat kangaroo.
Suitable for use in Immunofluorescence microscopy, Immunohistochemistry and Western Blot (Western). Immunohistochemistry: 1:10; Incubation Time 1 hr at RT.
50 µl deionized water
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C.
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B.