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LIN41 / TRIM71
tripartite motif containing 71, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1.
| Gene Name: | tripartite motif containing 71, E3 ubiquitin protein ligase |
| Synonyms: | TRIM71, Abnormal cell LINeage LIN-41, Homolog of C. elegans Lin-41, Protein lin-41 homolog, LIN41, Tripartite motif containing 71, Tripartite motif-containing 71, LIN-41 |
| Target Sequences: | NP_001034200.1 Q2Q1W2 |
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