LIN28B

lin-28 homolog B (C. elegans)

Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.

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Products

Antibodies (27)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (27)

Recombinant (2)

Target

LIN28B (31)

Reactivity

Human (26)

Mouse (4)

Rat (1)

Bovine (3)

Horse (3)

Pig (3)

Sheep (3)

Application

IHC (11)

IHC-P (3)

WB (22)

Flo (8)

ELISA (15)

ICC (5)

IF (11)

IP (2)

Host

rabbit (27)

Product Group

IHCPlus (2)

Isotype

IgG (19)

Clonality

polyclonal pc (27)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (16)

Epitope

aa1-30 (7)

C-Terminus (5)

aa1-50 (1)

aa200-250 (1)

aa218-250 (1)

Publications

No (30)

Yes (1)

Tag

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Purification

Purified (1)

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IHC-plus™ LIN28B Antibody (aa1-30) LS-B3423

(5.0) Rating

(2) Publication(s)

Antibody:

LIN28B Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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LIN28B Antibody LS-C748024

Antibody:

LIN28B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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IHC-plus™ LIN28B Antibody (aa1-50) LS-B15104

(4.0) Rating

Antibody:

LIN28B Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

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LIN28B Antibody (aa1-30) LS-C322667

Antibody:

LIN28B Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

LIN28B Antibody (aa1-30, Biotin) LS-C237139

Antibody:

LIN28B Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

LIN28B Antibody (aa1-30, FITC) LS-C250004

Antibody:

LIN28B Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

LIN28B Antibody (aa1-30, Azide-free, HRP) LS-C248710

Antibody:

LIN28B Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

LIN28B Antibody (aa1-30, APC) LS-C237138

Antibody:

LIN28B Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

LIN28B Antibody (aa1-30, PE) LS-C237140

Antibody:

LIN28B Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

Select

LIN28B Antibody LS-C755343

Antibody:

LIN28B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

LIN28B Antibody LS-C500855

Antibody:

LIN28B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

LIN28B Antibody (HRP) LS-C500854

Antibody:

LIN28B Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

LIN28B Antibody (Biotin) LS-C501076

Antibody:

LIN28B Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

LIN28B Antibody (FITC) LS-C501077

Antibody:

LIN28B Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

LIN28B Antibody LS-C748027

Antibody:

LIN28B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

LIN28B Antibody (aa200-250) LS-C290254

Antibody:

LIN28B Rabbit anti-Human Polyclonal (aa200-250) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

LIN28B Antibody (aa218-250) LS-C98241

Antibody:

LIN28B Rabbit anti-Human Polyclonal (aa218-250) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

LIN28B Antibody LS-C754404

Antibody:

LIN28B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

LIN28B Antibody LS-C781377

Antibody:

LIN28B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

LIN28B Antibody LS-C406154

Antibody:

LIN28B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

LIN28B Antibody LS-C402925

Antibody:

LIN28B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

LIN28B Antibody (C-Terminus) LS-C183948

Antibody:

LIN28B Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$688

Select

LIN28B Antibody (C-Terminus) LS-C345484

Antibody:

LIN28B Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

LIN28B Antibody (C-Terminus, FITC) LS-C453632

Antibody:

LIN28B Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Sheep, Bovine, Pig, Horse, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• FITC

• Unconjugated
• FITC

Select

LIN28B Antibody LS-C416887

Antibody:

LIN28B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Viewing 1-25 of 31 product results

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