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LIMPII / SCARB2
scavenger receptor class B, member 2
LIMPII / SCARB2 is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | scavenger receptor class B, member 2 |
| Synonyms: | SCARB2, AMRF, CD36 antigen-like 2, LGP85, Lysosome membrane protein 2, LIMPII, HLGP85, LIMP-2, SR-BII, CD36 antigen, CD36L2, EPM4, LIMP II, Lysosome membrane protein II |
| Target Sequences: | NM_005506 NP_005497.1 Q14108 |
Publications (4)
1
A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome. Balreira A, Gaspar P, Caiola D, Chaves J, Beiro I, Lima JL, Azevedo JE, Miranda MC. Human molecular genetics. 2008 17:2238-43.
[PubMed:18424452]
2
Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice. Kook S, Wang P, Young LR, Schwake M, Saftig P, Weng X, Meng Y, Neculai D, Marks MS, Gonzales L, Beers MF, Guttentag S. The Journal of biological chemistry. 2016 291:8414-27. (ICC, WB; Mouse, Human)
[Full Text Article]
[PubMed:26907692]
Related Antibodies: LS-B305, LS-B3225.
3
ß-Cyclodextrin counteracts obesity in Western diet-fed mice but elicits a nephrotoxic effect. Scantlebery AML, Ochodnicky P, Kors L, Rampanelli E, Butter LM, El Boumashouli C, Claessen N, Teske GJ, van den Bergh Weerman MA, Leemans JC, Roelofs JJTH, Florquin S. Science advances. 2019 November;9:17633. [Full Text Article]
[PubMed:31776357]
[PMC:PMC6881402]
Related Antibodies: LS-B305.
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LIMPII / SCARB2 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$460
LIMPII / SCARB2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
LIMPII / SCARB2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.59kD
10 µg/$304; 50 µg/$493; 500 µg/$1,585; 1 mg/$2,157
LIMPII / SCARB2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
0.1 mg/$460
LIMPII / SCARB2 Rabbit anti-Mouse Polyclonal Antibody
Mouse
Flo, ICC, IF, IHC, IHC-P
Unconjugated
100 µl/$412
LIMPII / SCARB2 Mouse anti-Human Monoclonal (1C8) Antibody
Human
ELISA
Unconjugated
100 µg/$423
LIMPII / SCARB2 Goat anti-Human Polyclonal (aa96-110) Antibody
Rabbit, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
LIMPII / SCARB2 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, IHC, IP, WB
Unconjugated
100 µl/$649
LIMPII / SCARB2 Rabbit anti-Human Polyclonal (aa25-74) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
LIMPII / SCARB2 Rabbit anti-Human Polyclonal (aa25-74) (HRP) Antibody
Bovine, Pig, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
LIMPII / SCARB2 Rabbit anti-Human Polyclonal (aa25-74) (Biotin) Antibody
Bovine, Pig, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
LIMPII / SCARB2 Rabbit anti-Human Polyclonal (aa25-74) (FITC) Antibody
Bovine, Pig, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
LIMPII / SCARB2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
LIMPII / SCARB2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
LIMPII / SCARB2 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P, WB
Unconjugated
100 µl/$412
LIMPII / SCARB2 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$412
LIMPII / SCARB2 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$412
LIMPII / SCARB2 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$412
LIMPII / SCARB2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
LIMPII / SCARB2 Rabbit anti-Mouse Polyclonal (APC) Antibody
Mouse
Flo
APC Conjugated
25 Tests/$293; 100 Tests/$376
LIMPII / SCARB2 Rabbit anti-Mouse Polyclonal (PE) Antibody
Mouse
Flo
PE Conjugated
25 Tests/$293; 100 Tests/$376
LIMPII / SCARB2 Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse
Flo
FITC Conjugated
25 Tests/$278; 100 Tests/$346
LIMPII / SCARB2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
LIMPII / SCARB2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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