LIMK2

LIM domain kinase 2

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.

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Products

Antibodies (45)

Proteins (9)

ELISA Kits (6)

Type

Cell-Based Phosphorylation (1)

Competitive EIA (1)

Custom (2)

Over-Expression Lysate (4)

Primary (45)

Recombinant (5)

Sandwich (2)

Target

LIMK2 (60)

Reactivity

Human (46)

Mouse (38)

Rat (28)

Bat (1)

Bovine (2)

Chicken (2)

Dog (1)

Horse (2)

Monkey (2)

Pig (1)

Rabbit (1)

Zebrafish (1)

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Application

IHC (24)

IHC-P (11)

WB (42)

ELISA (10)

ICC (3)

IF (10)

Peptide-ELISA (9)

Host

rabbit (42)

mouse (1)

goat (1)

sheep (1)

Isotype

IgG (34)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (44)

Clone

2H2-E11 (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (5)

APC Conjugated (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (40)

Epitope

pThr505 (7)

pSer283 (4)

220-300 aa (2)

Internal (2)

pSer291/Ser293 (2)

Asp499 (1)

Lys491 (1)

aa1-240 (1)

aa1-252 (1)

aa181-193 (1)

aa227-276 (1)

aa249-298 (1)

aa294-655 (1)

aa461-510 (1)

aa471-520 (1)

aa570-599 (1)

aa596-635 (1)

p505 (1)

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Publications

No (60)

Sample Type

Adherent Cell Cultures (1)

Plasma (3)

Serum (3)

Tag

GST (2)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (7)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (3)

Purification

Purified (2)

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LIMK2 Antibody (aa249-298) LS-C118289

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (aa249-298) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

LIMK2 Antibody (Internal) LS-C352456

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

LIMK2 Antibody (phospho-Ser283) LS-C801115

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (pSer283) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

LIMK2 Antibody LS-C822792

Antibody:

LIMK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

LIMK2 Antibody (aa461-510) LS-C118940

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (aa461-510) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

LIMK2 Antibody (phospho-Thr505) LS-C380758

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (pThr505) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

LIMK2 Antibody (aa294-655) LS-C185916

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (aa294-655) Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

Select

LIMK2 Antibody (aa1-252) LS-C186032

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (aa1-252) Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

Select

LIMK2 Antibody (phospho-Thr505) LS-C177921

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (pThr505) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$328; 100 µl/$419

Select

LIMK2 Antibody (Lys491) LS-C176914

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (Lys491) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

LIMK2 Antibody (phospho-Thr505) LS-C336024

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (pThr505) Antibody

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µl/$341; 100 µl/$431; 200 µl/$539

Select

LIMK2 Antibody (clone 2H2-E11) LS-C197617

Antibody:

LIMK2 Mouse anti-Human Monoclonal (2H2-E11) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

LIMK2 Antibody (phospho-Thr505) LS-C199202

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (pThr505) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

LIMK2 Antibody (220-300 aa) LS-C381615

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (220-300 aa) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

LIMK2 Antibody (phospho-Thr505) LS-C826308

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (pThr505) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

LIMK2 Antibody (aa1-240) LS-C376034

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (aa1-240) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

LIMK2 Antibody LS-C808665

Antibody:

LIMK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

LIMK2 Antibody (aa570-599) LS-C203840

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (aa570-599) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

LIMK2 Antibody (phospho-Ser291/Ser293) LS-C94270

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (pSer291/Ser293) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

500 µg/$393

Select

LIMK2 Antibody (Internal) LS-C94274

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

500 µg/$393

Select

LIMK2 Antibody (phospho-Thr505) LS-C123977

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (pThr505) Antibody

Reactivity:

Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Rat, Human, Monkey

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µg/$489

Select

LIMK2 Antibody (phospho-Ser283) LS-C199201

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (pSer283) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

LIMK2 Antibody LS-C342199

Antibody:

LIMK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

LIMK2 Antibody (phospho-Ser283) LS-C825345

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (pSer283) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

LIMK2 Antibody (phospho-Ser283) LS-C416720

Antibody:

LIMK2 Rabbit anti-Human Polyclonal (pSer283) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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