Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse, Rat (tested or 100% immunogen sequence identity)
Western blot (0.5 - 2 µg/ml)
Specificity and Use
LIME1 / LIME antibody was raised against synthetic peptide C-ENVYESIKEMGL from the C-terminus of mouse LIME1 / LIME (NP_076173.1). Percent identity by BLAST analysis: Mouse, Rat (100%); Bovine, Bat, Horse (83%).
LS-E25731 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C20175. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.