Bacteria LF / Lethal Factor

Mouse

Bacteria (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

LFA58

Unconjugated

Affinity purified

Unmodified

Highly purified Bacillus anthracis lethal factor.

Recognizes the Lethal Factor of the anthrax toxin. Bacillus anthracis produces a toxin composed of three proteins, the Protective Antigen (PA), the Edema Factor (EF) and the Lethal Factor (LF). The three proteins depend on each other for their toxic effect. Both EF and LF functions intracellularly but are too large to enter the cell through existing channels. The PA is responsible for transporting the EF and LF into cells. The LF acts as an endoprotease, removing the N-terminus of mitogen-activated protein kinase kinases (MAPKK). The kinases are prevented from binding to their substrates, which leads to altered signalling pathways and ultimately to apoptosis. May be used as a capture antibody in ELISA assays for the Lethal Factor of Bacillus anthracis.

• Western blot
• ELISA

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P15917 NCBI: P15917