LCP2 / SLP-76

lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

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Products

Antibodies (56)

ELISA Kits (8)

Proteins (8)

Type

Custom (1)

Over-Expression Lysate (2)

Primary (56)

Recombinant (6)

Sandwich (7)

Target

LCP2 / SLP-76 (72)

Reactivity

Human (58)

Mouse (41)

Rat (19)

Bat (1)

Chicken (1)

Monkey (2)

Pig (7)

Porcine (2)

Rabbit (2)

Sheep (1)

Application

IHC (18)

IHC-Fr (1)

IHC-P (8)

WB (54)

Flo (1)

ELISA (9)

IF (4)

IP (6)

Peptide-ELISA (4)

Host

rabbit (43)

mouse (12)

goat (1)

Product Group

IHCPlus (2)

Isotype

Ig (2)

IgG (23)

IgG1 (1)

IgG2a (1)

IgG2b (10)

Clonality

monoclonal mc (12)

polyclonal pc (44)

Clone

H76 (1)

Polyclonal (1)

SLP-76/03 (5)

Format

96-Well Strip Plate (8)

APC (1)

APC Conjugated (1)

Biotin Conjugated (2)

Concentrated (2)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (45)

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Epitope

aa202-463 (8)

aa216-434 (8)

pTyr128 (4)

70-150 aa (2)

Internal (2)

270-350 aa, Internal (1)

Gly122 (1)

N-Terminus (1)

Ser376 (1)

Tyr145 (1)

Tyr173 (1)

aa1-533 (1)

aa2-12 (1)

aa200-250 (1)

aa225-275 (1)

aa339-384 (1)

aa73-122 (1)

aa94-143 (1)

p128 (1)

pTyr145 (1)

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Publications

No (71)

Yes (1)

Sample Type

Cell Supernatant (1)

Plasma (2)

Serum (2)

Tag

6His, C-terminus (1)

GST (2)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

T7, N-terminus + 6His, C-terminus (1)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

Select

LCP2 / SLP-76 Antibody (aa94-143) LS-C118332

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal (aa94-143) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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IHC-plus™ LCP2 / SLP-76 Antibody (aa216-434, clone Polyclonal) LS-B3732

(4.0) Rating

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal (aa216-434) (Polyclonal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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LCP2 / SLP-76 Antibody (aa216-434, clone H76) LS-C41105

(4.0) Rating

(1) Publication(s)

Antibody:

LCP2 / SLP-76 Mouse anti-Human Monoclonal (aa216-434) (H76) Antibody

Reactivity:

Human

Applications:

Flo, IP, WB

Format:

Unconjugated

Price:

50 µl/$276

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IHC-plus™ LCP2 / SLP-76 Antibody (aa216-434, clone SLP-76/03) LS-B1879

(4.0) Rating

Antibody:

LCP2 / SLP-76 Mouse anti-Human Monoclonal (aa216-434) (SLP-76/03) Antibody

Reactivity:

Mouse, Porcine, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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Mouse LCP2 / SLP-76 Protein (Recombinant His, N-Terminal) (aa202-463) - LS-G13476

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.9 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human LCP2 / SLP-76 Protein (Recombinant GST) (Full Length) - LS-G29182

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

84.37 kDa

Price:

10 µg/$479; 25 µg/$670

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Human LCP2 / SLP-76 Protein (Recombinant T7, N-terminus + 6His, C-terminus) (Met1-Pro533) - LS-G39845

Source:

E. coli

Tag:

T7, N-terminus + 6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

62.6kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

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LCP2 / SLP-76 Antibody (phospho-Tyr128) LS-C199576

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal (pTyr128) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

LCP2 / SLP-76 Antibody (aa216-434, clone SLP-76/03) LS-C44763

Antibody:

LCP2 / SLP-76 Mouse anti-Human Monoclonal (aa216-434) (SLP-76/03) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

0.1 mg/$385

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LCP2 / SLP-76 Antibody LS-C39118

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$688

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LCP2 / SLP-76 Antibody LS-C754901

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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Human LCP2 / SLP-76 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81467

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

20 µg/$150

Select

LCP2 / SLP-76 Antibody LS-C332172

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

LCP2 / SLP-76 Antibody (70-150 aa) LS-C386092

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal (70-150 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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LCP2 / SLP-76 Antibody LS-C39119

Antibody:

LCP2 / SLP-76 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Pig, Human

Applications:

IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

100 µg/$597

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LCP2 / SLP-76 Antibody (HRP) LS-C549481

Antibody:

LCP2 / SLP-76 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Mouse, Pig, Human

Applications:

IHC, WB

Format:

HRP Conjugated

Price:

100 µl/$836

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LCP2 / SLP-76 Antibody (Biotin) LS-C529393

Antibody:

LCP2 / SLP-76 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Mouse, Pig, Human

Applications:

IHC, WB

Format:

Biotin Conjugated

Price:

100 µl/$836

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LCP2 / SLP-76 Antibody (FITC) LS-C539314

Antibody:

LCP2 / SLP-76 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Mouse, Pig, Human

Applications:

IHC, WB

Format:

FITC Conjugated

Price:

100 µl/$836

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LCP2 / SLP-76 Antibody (PE) LS-C657460

Antibody:

LCP2 / SLP-76 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Mouse, Pig, Human

Applications:

IHC, WB

Format:

PE Conjugated

Price:

100 µl/$836

• Unconjugated
• HRP
• Biotin
• FITC
• PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE

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LCP2 / SLP-76 Antibody (70-150 aa) LS-C381393

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal (70-150 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

LCP2 / SLP-76 Antibody (p128) LS-C825485

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal (p128) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

LCP2 / SLP-76 Antibody (phospho-Tyr128) LS-C825487

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal (pTyr128) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

LCP2 / SLP-76 Antibody (aa73-122) LS-C200704

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal (aa73-122) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

LCP2 / SLP-76 Antibody (Gly122) LS-C177790

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal (Gly122) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

LCP2 / SLP-76 Antibody LS-C341302

Antibody:

LCP2 / SLP-76 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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