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Anti-LCP2 / SLP-76 Antibody (aa216-434, clone SLP-76/03) LS-C204152


Wt. Vol. Conc. Price
100 µg - 1 mg/ml Unavailable

Most Popular LCP2 / SLP-76 Antibodies

Anti-LCP2 / SLP-76 Antibody (aa216-434, clone H76) LS-C41105
Mouse Monoclonal [clone H76] (IgG2a) to Human LCP2 / SLP-76
Western blot, Immunoprecipitation, Flow Cytometry
Western blot Image
Anti-LCP2 / SLP-76 Antibody (aa216-434, clone SLP-76/03) IHC-plus™ LS-B1879
Mouse Monoclonal [clone SLP-76/03] (IgG2b) to Human LCP2 / SLP-76
Human, Mouse, Pig
IHC - Paraffin, Western blot
Immunohistochemistry Image
Anti-LCP2 / SLP-76 Antibody (aa216-434) IHC-plus™ LS-B3732
Rabbit Polyclonal to Human LCP2 / SLP-76
IHC - Paraffin, Western blot, Inhibition
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone SLP-76/03] (IgG2b) to Human LCP2 / SLP-76
Western blot


Human LCP2 / SLP-76
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [SLP-76/03]


Western blot

Specificity and Use

LCP2 / SLP-76 antibody was raised against a fusion protein representing amino acids 216-434 of human SLP-76.
SLP-76 (SH2 domain-containing leukocyte protein) is an adaptor molecule that is involved in T cell development and activation. Thymocytes from transgenic mice expressing a SLP-76 mutant with deletion of the amino terminus are unable to develop to CD4-CD8- stage. Mature T cells do develop in mice expressing SLP-76 with mutations in proline rich region or SH2 domain, but they fail to upregulate CD69 or proliferate appropriately in response to anti-CD3 stimulation. SLP-76 is cytosolic protein identified as phosphoprotein migrating at 76 kD in SDS-PAGE. Amino-terminal domain of SLP-76 containing several tyrosines is followed by PR (proline rich) region and an SH2 domain. SLP-76 associates with LAT via Gads or Grb 2. The PR region of SLP-76 constitutively associates with carboxy-terminal SH3 domain of Gads and P-1 segment of the PR region was also identified that associates with the SH3 domain of PLC-gamma1. The PR region therefore provides another pathway for PLC-gamma1 recruitment to the LAT signalling complex in T cells. The SH2 domain of SLP-76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.


PBS, pH 7.4, 15 mM sodium azide
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About LCP2 / SLP-76

Q13094 NM_005565 NP_005556.1

LCP2 Antibody, 76 kDa tyrosine phosphoprotein Antibody, Lymphocyte cytosolic protein 2 Antibody, SLP-76 Antibody, SLP-76 tyrosine phosphoprotein Antibody, SLP76 Antibody

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains.

Requested From: 
Date Requested: 3/28/2017

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