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LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
| Gene Name: | late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 |
| Synonyms: | LAMTOR2, Endosomal adaptor protein p14, HSPC003, MAPBPIP, MAPKSP1AP, p14, Roadblock domain containing 3, MAPKSP1 adaptor protein, RP11-336K24.9, ENDAP, Ragulator2, ROBLD3 |
| Target Sequences: | NM_014017 NP_054736.1 Q9Y2Q5 |
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