Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Human, Mouse (tested or 100% immunogen sequence identity)
Bovine (at least 90% immunogen sequence identity)
IHC - Paraffin (1:25 - 1:100)
ICC (1:25 - 1:100)
Immunofluorescence (1:25 - 1:100)
Western blot (1:1000)
Specificity and Use
LAMTOR1 antibody was raised against a genomic peptide made to an C-terminal region of the human c11orf59 protein (within residues 50-250). [Swiss-Prot Q6IAA8]. Percent identity by BLAST analysis: Bovine (98%).
PBS, 0.1% BSA, 50% glycerol, 0.05% sodium azide
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.