Dog LAMP2 / CD107b

Mouse

Dog (tested or 100% immunogen sequence identity)

Mouse, Rat

IgG1 Monoclonal

AC17

Unconjugated. Also available conjugated with FITC.

Protein G purified

Unmodified

MDCK (Madin-Darby Canine Kidney) cells.

Recognizes canine CD107b, otherwise known as LAMP-2, a 95kD heavily-glycosylated type I integral lysosomal glycoprotein, shown to share high N-terminal amino acid sequence homology with human, mouse and rat CD107b. Lysosomes are membrane-bound organelles found within the cytoplasm of most cells, which contain hydrolytic enzymes and act as the major compartment for heterophagic and autophagic digestion. Members of the lysosomal-associated membrane protein family (LAMPS) are believed to play an important role in protecting the lysosomal membrane from protease degradation and are involved in lectin-mediated cell adhesion. Evidence shows that CD107b is involved in the lysosomal uptake of cytosolic proteins and the endocytic pathway and human studies have revealed a correlation between the level of surface expression of CD107b on tumor cells and their metastatic potential. Clone AC17 has been shown as suitable for use in Electron Microscopy.

• Immunofluorescence
• Western blot (1:100 - 1:500)
• Immunoprecipitation
• Flow Cytometry

PBS, 0.09% Sodium Azide

Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P13473 NCBI: NM_013995 NP_054701.1