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Anti-LAG3 Antibody (Low Endotoxin) LS-C44773

Ordering

Wt. Vol. Conc. Price
500 µg - 1 mg/ml $450
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular LAG3 Antibodies

Anti-LAG3 Antibody (clone 17B4) LS-C18692
Mouse Monoclonal [clone 17B4] (IgG1) to Human LAG3
Human
IHC - Frozen, ICC, Western blot, Immunoprecipitation
Unconjugated
Anti-LAG3 Antibody (aa70-99, clone 17B4, FITC) IHC-plus™ LS-B2237
Mouse Monoclonal [clone 17B4] (IgG1) to Human LAG3
Human
IHC - Paraffin, Flow Cytometry
FITC Conjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rat Monoclonal (IgG1) to Mouse LAG3
Mouse
Flow Cytometry, Functional Assay (applications tested for the base form of this product only)
Unconjugated, Low Endotoxin

Details

Mouse LAG3
Rat
Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal
Unconjugated
Protein G purified
Low Endotoxin. Also available Unmodified.

Applications

  • Flow Cytometry (1:50 - 1:200)
  • Functional Assay
  • (applications tested for the base form of this product only)

Specificity and Use

LAG3 antibody was raised against murine CD223 Ig fusion protein.
Recognizes murine lymphocyte activation gene-3 (LAG-3), a 70kD activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Recognizes an epitope within the D2 domain of CD223. The antibody is reported to block the in vitro function of murine LAG-3 but studies suggest that the antibody does not block binding of LAG-3 to MHC class II.
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request.

Packaging

PBS, pH 7.4.
Store at -20°C. Aliquot to avoid freeze/thaw cycles.
For research use only.

About LAG3

P18627 NM_002286 P18627

LAG3 Antibody, CD223 antigen Antibody, LAG-3 Antibody, Protein FDC Antibody, CD223 Antibody, FDC Antibody, Lymphocyte-activation gene 3 Antibody

Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.

Requested From: United States
Date Requested: 12/9/2016

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