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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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LAG3 Antibody (clone C9B7W, RPE) LS‑C44775
Note: This antibody replaces LS-C57926, LS-C37141
Antibody
LAG3 antibody LS-C44775 is an RPE-conjugated rat monoclonal antibody to mouse LAG3. Validated for Flow.
Catalog
Size
Price
LS-C44775-100
100 tst
Unavailable

Popular LAG3 Products

Antibody
Species: Human, Monkey
Applications: IHC, IHC - Frozen, ICC, Western blot, Immunoprecipitation, ELISA
Antibody
Species: Human
Applications: IHC, IHC - Frozen, ICC, Western blot, Immunoprecipitation
Anti-LAG-3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2237 concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: IHC, IHC - Paraffin, Flow Cytometry
Antibody
Species: Human
Applications: Flow Cytometry
Antibody
Species: Human
Applications: IHC, IHC - Frozen, ICC, Western blot, Immunoprecipitation, Flow Cytometry, Functional Assay

Product Description

LAG3 antibody LS-C44775 is an RPE-conjugated rat monoclonal antibody to mouse LAG3. Validated for Flow.
About LAG3
Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. P18627 NM_002286 P18627

LAG3 Antibody, CD223 antigen Antibody, LAG-3 Antibody, Protein FDC Antibody, CD223 Antibody, FDC Antibody, Lymphocyte-activation gene 3 Antibody


Specifications

Target
Mouse LAG3
Host
Rat
Reactivity
Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [C9B7W]
Conjugations
R. Phycoerythrin. Also available Unconjugated.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Flow Cytometry (1:1 - 1:5)
  • (applications tested for the base form of this product only)
Immunogen
LAG3 antibody was raised against murine CD223 Ig fusion protein.
Specificity
Recognizes murine lymphocyte activation gene-3 (LAG-3), a 70kD activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Recognizes an epitope within the D2 domain of CD223. The antibody is reported to block the in vitro function of murine LAG-3 but studies suggest that the antibody does not block binding of LAG-3 to MHC class II. XXX recommend the use of MCA2386EL for this purpose.
Usage
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors.
Presentation
Lyophilized powder from PBS, pH 7.4, 0.09% sodium azide, 1% BSA, 5% sucrose.
Reconstitution
100 tst Reconstitute with 1.0 ml distilled water.
Storage
Store at 4°C. Do not freeze. Protect from light.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/18/2018

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