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Anti-LAG3 Antibody (aa70-99, clone 17B4) LS-C18692

Catalog Size Price
LS-C18692-100 100 µg (1 mg/ml) Unavailable

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Anti-LAG3 Antibody (aa70-99, clone 17B4) LS-C18692
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Anti-LAG3 Antibody (aa70-99, clone 17B4, FITC) IHC-plus™ LS-B2237
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Anti-LAG-3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2237 concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-LAG3 Antibody (Extracellular Domain, PerCP) LS-C130398
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Anti-LAG3 Antibody (aa70-99, clone 17B4, FITC) LS-C344745
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100% Guaranteed Publications (3)
Mouse Monoclonal [clone 17B4] (IgG1) to Human LAG3
Human
IHC, IHC - Frozen, ICC, Western blot, Immunoprecipitation
Unconjugated

Details

Human LAG3
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [17B4]
Unconjugated
Protein A purified
Unmodified

Applications

  • IHC
  • IHC - Frozen (1:150)
  • ICC
  • Western blot (5 µg/ml)
  • Immunoprecipitation (10 µg/ml)

Specificity and Use

LAG3 antibody was raised against synthetic peptide corresponding to 30 aa (GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY) from the first N-terminal D1 domain of human LAG-3 (lymphocyte activation gene-3). Percent identity by BLAST analysis: Human (100%); Gorilla (93%); Gibbon (90%); Monkey (83%).
aa70-99
Recognizes the 30 aa extra-loop of the first N-terminal D1 domain of human LAG-3.

Packaging

Supplied as a liquid in PBS containing 10% glycerol and 0.02% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
For research use only.

Publications (3)

1
Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade. Taube JM, Young GD, McMiller TL, Chen S, Salas JT, Pritchard TS, Xu H, Meeker AK, Fan J, Cheadle C, Berger AE, Pardoll DM, Topalian SL. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 21:3969-76. (IHC; Human) [Full Text Article] [PubMed:25944800] [PMC:PMC4558237]
2
Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade. Chen PL, Roh W, Reuben A, Cooper ZA, Spencer CN, Prieto PA, Miller JP, Bassett RL, Gopalakrishnan V, Wani K, De Macedo MP, Austin-Breneman JL, Jiang H, Chang Q, Reddy SM, Chen WS, Tetzlaff MT, Broaddus RJ, Davies MA, Gershenwald JE, Haydu L, Lazar AJ, Patel SP, Hwu P, Hwu WJ, Diab A, Glitza IC, Woodman SE, Vence LM, Wistuba II, Amaria RN, Kwong LN, Prieto V, Davis RE, Ma W, Overwijk WW, Sharpe AH, Hu J, Futreal PA, Blando J, Sharma P, Allison JP, Chin L, Wargo JA. Cancer discovery. 2016 6:827-37. (IHC; Human) [Full Text Article] [PubMed:27301722] [PMC:PMC5082984]
3
The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects. Tian X, Zhang A, Qiu C, Wang W, Yang Y, Qiu C, Liu A, Zhu L, Yuan S, Hu H, Wang W, Wei Q, Zhang X, Xu J. Journal of immunology (Baltimore, Md. : 1950). 2015 194:3873-82. (IHC; Human) [Full Text Article] [PubMed:25780040]

About LAG3

P18627 NM_002286 P18627

LAG3 Antibody, CD223 antigen Antibody, LAG-3 Antibody, Protein FDC Antibody, CD223 Antibody, FDC Antibody, Lymphocyte-activation gene 3 Antibody

Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.

Requested From: 
Date Requested: 4/24/2018

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