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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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LAG3 Antibody (aa70‑99, clone 17B4) LS‑C18692
Antibody
LAG3 antibody LS-C18692 is an unconjugated mouse monoclonal antibody to human LAG3. Validated for ICC, IHC, IP and WB. Cited in 3 publications.
Catalog
Size
Price
LS-C18692-100
100 µg (1 mg/ml)
Unavailable

Popular LAG3 Products

Antibody
Species: Human, Monkey
Applications: IHC, IHC - Frozen, ICC, Western blot, Immunoprecipitation, ELISA
Anti-LAG-3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2237 concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: IHC, IHC - Paraffin, Flow Cytometry
Antibody
Species: Human
Applications: Flow Cytometry
Antibody
Species: Human
Applications: IHC, IHC - Frozen, ICC, Western blot, Immunoprecipitation, Flow Cytometry, Functional Assay

Product Description

LAG3 antibody LS-C18692 is an unconjugated mouse monoclonal antibody to human LAG3. Validated for ICC, IHC, IP and WB. Cited in 3 publications.
About LAG3
Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. P18627 NM_002286 P18627

LAG3 Antibody, CD223 antigen Antibody, LAG-3 Antibody, Protein FDC Antibody, CD223 Antibody, FDC Antibody, Lymphocyte-activation gene 3 Antibody


Specifications

Target
Human LAG3
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [17B4]
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Frozen (1:150)
  • ICC
  • Western blot (5 µg/ml)
  • Immunoprecipitation (10 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
LAG3 antibody was raised against synthetic peptide corresponding to 30 aa (GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY) from the first N-terminal D1 domain of human LAG-3 (lymphocyte activation gene-3). Percent identity by BLAST analysis: Human (100%); Gorilla (93%); Gibbon (90%); Monkey (83%).
Epitope
aa70-99
Specificity
Recognizes the 30 aa extra-loop of the first N-terminal D1 domain of human LAG-3.
Presentation
Supplied as a liquid in PBS containing 10% glycerol and 0.02% sodium azide.
Storage
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

Publications (3)

1
Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade. Taube JM, Young GD, McMiller TL, Chen S, Salas JT, Pritchard TS, Xu H, Meeker AK, Fan J, Cheadle C, Berger AE, Pardoll DM, Topalian SL. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 21:3969-76. (IHC; Human) [Full Text Article] [PubMed:25944800] [PMC:PMC4558237]
2
Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade. Chen PL, Roh W, Reuben A, Cooper ZA, Spencer CN, Prieto PA, Miller JP, Bassett RL, Gopalakrishnan V, Wani K, De Macedo MP, Austin-Breneman JL, Jiang H, Chang Q, Reddy SM, Chen WS, Tetzlaff MT, Broaddus RJ, Davies MA, Gershenwald JE, Haydu L, Lazar AJ, Patel SP, Hwu P, Hwu WJ, Diab A, Glitza IC, Woodman SE, Vence LM, Wistuba II, Amaria RN, Kwong LN, Prieto V, Davis RE, Ma W, Overwijk WW, Sharpe AH, Hu J, Futreal PA, Blando J, Sharma P, Allison JP, Chin L, Wargo JA. Cancer discovery. 2016 6:827-37. (IHC; Human) [Full Text Article] [PubMed:27301722] [PMC:PMC5082984]
3
The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects. Tian X, Zhang A, Qiu C, Wang W, Yang Y, Qiu C, Liu A, Zhu L, Yuan S, Hu H, Wang W, Wei Q, Zhang X, Xu J. Journal of immunology (Baltimore, Md. : 1950). 2015 194:3873-82. (IHC; Human) [Full Text Article] [PubMed:25780040]

Customer Reviews (0)


Requested From: 
Date Requested: 6/21/2018

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