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Shirley, MA 01464
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LAF4 / AFF3
AF4/FMR2 family, member 3
LAF4 / AFF3 is a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
| Gene Name: | AF4/FMR2 family, member 3 |
| Synonyms: | AFF3, AF4/FMR2 family member 3, AF4/FMR2 family, member 3, LAF4, MLLT2-like, MLLT2-related protein, Lymphoid nuclear protein 4, Protein LAF-4 |
| Target Sequences: | NM_002285 NP_002276.2 P51826 |
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