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L1CAM

L1 cell adhesion molecule

L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

Gene Name: L1 cell adhesion molecule
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: L1CAM, CAML1, CD171 antigen, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, L1 cell adhesion molecule, NCAM-L1, S10, SPG1, CD171
Target Sequences: NP_000416.1 P32004

Publications (3)

1
An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage. Jae-Kyung Nam , A-Ram Kim , Seo-Hyun Choi , Ji-Hee Kim, Kyu Jin Choi, Seulki Cho, Jae Won Lee, Hyun-Jai Cho, Yoo-Wook Kwon, Jaeho Cho, Kwang Seok Kim, Joon Kim, Hae-June Lee, Tae Sup Lee, Sangwoo Bae, Hyo Jeong Hong, Yoon-Jin Lee. Nature communications. 2021 June;12:3279. [Full Text Article] [PubMed:34078883] [PMC:PMC8172563] Related Antibodies: LS-B9803.
2
Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats. Raghubendra Singh Dagur, Ke Liao, Susmita Sil, Fang Niu, Zhiqiang Sun, Yuri L Lyubchenko, Eric S Peeples, Guoku Hu, Shilpa Buch. Journal of Extracellular Vesicles. 2020 Dec;9:1703249. [Full Text Article] [PubMed:32002168] [PMC:PMC6968593] Related Antibodies: LS-C470565.
3
Preoperative Risk Stratification of Endometrial Carcinoma: L1CAM as a Biomarker. Annukka Pasanen, Mikko Loukovaara, Taru Tuomi, Ralf Bützow. The Breast : official journal of the European Society of Mastology. 2017 Sep;;27:1318-1324. [Full Text Article] [PubMed:29059097]

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Antibodies (118)
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L1CAM Antibody - Anti-L1CAM antibody IHC staining of human peripheral nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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L1CAM Rabbit anti-Human Polyclonal (aa1154-1182) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
L1CAM Antibody - Anti-L1CAM antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Neuroscience
L1CAM Mouse anti-Human Monoclonal (UJ127.11) Antibody
Human
IHC, IHC-P
Unconjugated
0.1 mg/$460
L1CAM Antibody - IHC of paraffin-embedded Adenocarcinoma of colon tissue using anti-L1CAM mouse monoclonal antibody. (Dilution 1:50).
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L1CAM Mouse anti-Human Monoclonal (OTI2H5) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
L1CAM Antibody - IHC of paraffin-embedded Adenocarcinoma of colon tissue using anti-L1CAM mouse monoclonal antibody. (Dilution 1:50).
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L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI2H5) Antibody
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
L1CAM Antibody - L1CAM antibody Western blot of Fetal Brain lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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L1CAM Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
L1CAM Antibody - L1CAM antibody Western blot of Fetal Brain lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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L1CAM Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
L1CAM ELISA Kit
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Sandwich
96-Well Microplate
Human
93.75 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
L1CAM Antibody - IHC of paraffin-embedded breast tissue using anti-L1CAM mouse monoclonal antibody. (Dilution 1:50).
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L1CAM Mouse anti-Human Monoclonal (OTI4F4) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
L1CAM Antibody - IHC of paraffin-embedded breast tissue using anti-L1CAM mouse monoclonal antibody. (Dilution 1:50).
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L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI4F4) Antibody
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
L1CAM Protein - Recombinant L1-Cell Adhesion Molecule By SDS-PAGE
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E. coli
His-GST
59.9 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
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L1CAM Rabbit anti-Human Monoclonal (Preservative Free) (014) Antibody
Human
ELISA, Flo, ICC, IF, IHC-P
Unconjugated, Preservative Free
20 µl/$286; 100 µl/$435
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L1CAM Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$535
L1CAM Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
140 kDa
100 µg/$710
L1CAM Antibody - Immunofluorescent analysis of L1CAM staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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L1CAM Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Rat, Mouse, Human
ICC, IF, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
L1CAM Antibody - Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-L1CAM mouse monoclonal antibody.
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L1CAM Mouse anti-Human Monoclonal (OTI2H6) Antibody
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
L1CAM Antibody - Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-L1CAM mouse monoclonal antibody.
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L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI2H6) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
L1CAM Antibody - IHC of paraffin-embedded liver tissue using anti-L1CAM mouse monoclonal antibody. (Dilution 1:50).
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L1CAM Mouse anti-Human Monoclonal (OTI2C7) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
L1CAM Antibody - IHC of paraffin-embedded liver tissue using anti-L1CAM mouse monoclonal antibody. (Dilution 1:50).
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L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI2C7) Antibody
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
L1CAM Antibody - IHC of paraffin-embedded breast tissue using anti-L1CAM mouse monoclonal antibody. (Dilution 1:50).
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L1CAM Mouse anti-Human Monoclonal (OTI2A6) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
L1CAM Antibody - IHC of paraffin-embedded breast tissue using anti-L1CAM mouse monoclonal antibody. (Dilution 1:50).
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L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI2A6) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
L1CAM Antibody - Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-L1CAM mouse monoclonal antibody. (Dilution 1:50).
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L1CAM Mouse anti-Human Monoclonal (OTI3G1) Antibody
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
L1CAM Antibody - Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-L1CAM mouse monoclonal antibody. (Dilution 1:50).
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L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI3G1) Antibody
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
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L1CAM Rabbit anti-Human Polyclonal (aa1154-1182) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
L1CAM Antibody - Immunohistochemical staining of paraffin-embedded human ovcarian carcinoma using anti-L1CAM clone UMAB47 mouse monoclonal antibody at 1:200 with Polink2 Broad HRP DAB detection kit ; heat-induced epitope retrieval with citrate buffer, pH6.0at 95-100C. Cytoplasmic and membraneous staining is seen in tumor cells.
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L1CAM Mouse anti-Human Monoclonal (UMAB47) Antibody
Human
IF, IHC, PMA, WB
Unconjugated
100 µl/$493
L1CAM Antibody - Immunohistochemical staining of paraffin-embedded human ovcarian carcinoma using anti-L1CAM clone UMAB47 mouse monoclonal antibody at 1:200 with Polink2 Broad HRP DAB detection kit ; heat-induced epitope retrieval with citrate buffer, pH6.0at 95-100C. Cytoplasmic and membraneous staining is seen in tumor cells.
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L1CAM Mouse anti-Human Monoclonal (Carrier-free) (UMAB47) Antibody
Human
IF, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
Viewing 1-25 of 141 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).