KSR1

kinase suppressor of ras 1

Kinase suppressor of Ras (KSR) is involved in the regulation of the Ras activated MAPK pathway. KSR contains some kinase activity, phosphorylating Raf-1 at Thr269 in response to Ras stimulation. One study found this was necessary for the optimal activation of Raf-1 in response to EGF. Further studies popularly supported the idea that KSR acts as a scaffolding protein for the Ras stimulated MAPK pathway by supporting the formation of a large complex. Within human embryonic kidney cells KSR forms part of a multimolecular complex consisting of MEK1, MEK2, HSP90, HSP70, HSP68, p50CDC37, and 14-3-3, along with other currently unidentified proteins. The binding of protein 14-3-3 to KSR is associated with KSR phosphorylation sites Ser297 and Ser392. These sites are phosphorylated when KSR is inactive. Three other important sites on KSR are Thr260, Thr274, and Ser443, which appear to be phosphorylated by active MAPKs. Inactive ERK MAPKs may also transiently associate with the complex. These kinases will be phosphorylated by the MEK part of the KSR signaling complex.

☰ Filters

Products

Antibodies (41)

ELISA Kits (5)

Proteins (1)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Custom (1)

Primary (41)

Recombinant (1)

Sandwich (2)

Target

KSR1 (47)

Reactivity

Human (38)

Mouse (24)

Rat (8)

Monkey (1)

Application

IHC (14)

IHC-P (4)

WB (41)

ELISA (28)

ICC (1)

IF (5)

Peptide-ELISA (1)

Host

rabbit (35)

mouse (6)

Isotype

IgG (30)

IgG2a,k (6)

Clonality

monoclonal mc (6)

polyclonal pc (35)

Format

96-Well Microplate (2)

96-Well Strip Plate (3)

APC Conjugated (4)

Azide-free (3)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (4)

Unconjugated (21)

Epitope

aa1-30 (7)

aa159-194 (7)

aa719-747 (7)

pSer392 (2)

Arg386 (1)

Internal (1)

aa301-400 (1)

aa358-407 (1)

p392 (1)

pSer404 (1)

Publications

No (47)

Sample Type

Adherent Cell Cultures (2)

Plasma (2)

Serum (2)

Tissue Homogenates (1)

Tag

GST, N-terminus (1)

Species

Human (1)

Source

Wheat Germ Extract (1)

Select

KSR1 Antibody (Internal) LS-C358791

Antibody:

KSR1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

Select

KSR1 Antibody (phospho-Ser392) LS-C825844

Antibody:

KSR1 Rabbit anti-Human Polyclonal (pSer392) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

KSR1 Antibody (aa358-407) LS-C117567

Antibody:

KSR1 Rabbit anti-Human Polyclonal (aa358-407) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

KSR1 Antibody (Arg386) LS-C176570

Antibody:

KSR1 Rabbit anti-Human Polyclonal (Arg386) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

KSR1 Antibody (p392) LS-C825845

Antibody:

KSR1 Rabbit anti-Human Polyclonal (p392) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

KSR1 Antibody LS-C814167

Antibody:

KSR1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

KSR1 Antibody (aa1-30) LS-C327735

Antibody:

KSR1 Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

KSR1 Antibody (aa1-30, Biotin) LS-C219904

Antibody:

KSR1 Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

KSR1 Antibody (aa1-30, FITC) LS-C219908

Antibody:

KSR1 Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

KSR1 Antibody (aa1-30, APC) LS-C219903

Antibody:

KSR1 Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

KSR1 Antibody (aa1-30, PE) LS-C219909

Antibody:

KSR1 Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

KSR1 Antibody (aa1-30, Azide-free, HRP) LS-C219906

Antibody:

KSR1 Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

KSR1 Antibody LS-C814165

Antibody:

KSR1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

KSR1 Antibody (aa1-30) LS-C97199

Antibody:

KSR1 Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

KSR1 Antibody (aa719-747) LS-C329754

Antibody:

KSR1 Rabbit anti-Mouse Polyclonal (aa719-747) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

KSR1 Antibody (aa719-747, Biotin) LS-C215551

Antibody:

KSR1 Rabbit anti-Mouse Polyclonal (aa719-747) (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

KSR1 Antibody (aa719-747, FITC) LS-C215552

Antibody:

KSR1 Rabbit anti-Mouse Polyclonal (aa719-747) (FITC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

KSR1 Antibody (aa719-747, APC) LS-C215550

Antibody:

KSR1 Rabbit anti-Mouse Polyclonal (aa719-747) (APC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

KSR1 Antibody (aa719-747, Azide-free, HRP) LS-C215553

Antibody:

KSR1 Rabbit anti-Mouse Polyclonal (aa719-747) (Azide-free) (HRP) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

KSR1 Antibody (aa719-747, PE) LS-C215558

Antibody:

KSR1 Rabbit anti-Mouse Polyclonal (aa719-747) (PE) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

KSR1 Antibody (aa301-400) LS-C309170

Antibody:

KSR1 Mouse anti-Human Monoclonal (aa301-400) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$705

Select

KSR1 Antibody (Biotin) LS-C522778

Antibody:

KSR1 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

Select

KSR1 Antibody (PE) LS-C651023

Antibody:

KSR1 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

100 µl/$904

Select

KSR1 Antibody (APC) LS-C514563

Antibody:

KSR1 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

100 µl/$904

• Unconjugated
• Biotin
• PE
• APC

• Unconjugated
• Biotin
• PE
• More...
  • APC

Select

KSR1 Antibody (aa159-194) LS-C327734

Antibody:

KSR1 Rabbit anti-Human Polyclonal (aa159-194) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Viewing 1-25 of 47 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.