Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
KSR1 Antibody, B-KSR1 Antibody, KSR Antibody, RSU2 Antibody, Kinase suppressor of ras Antibody, Kinase suppressor of ras 1 Antibody
Kinase suppressor of Ras (KSR) is involved in the regulation of the Ras activated MAPK pathway. KSR contains some kinase activity, phosphorylating Raf-1 at Thr269 in response to Ras stimulation. One study found this was necessary for the optimal activation of Raf-1 in response to EGF. Further studies popularly supported the idea that KSR acts as a scaffolding protein for the Ras stimulated MAPK pathway by supporting the formation of a large complex.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of anti-KSR1 antibody in A375 cell lysate. KSR1 (arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.