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| Catalog Number | Size | Price |
|---|---|---|
| LS-B1846-0.05 | 0.05 mg (1 mg/ml) | $440 |
PathPlus™ Monoclonal Mouse anti‑Human KRT8 / CK8 / Cytokeratin 8 Antibody (clone C‑43, IHC, WB) LS‑B1846
PathPlus™ Monoclonal Mouse anti‑Human KRT8 / CK8 / Cytokeratin 8 Antibody (clone C‑43, IHC, WB) LS‑B1846
Note: This antibody replaces LS-C45740
Antibody:
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (C-43) Antibody
Application:
IHC, IHC-P, ICC, WB, IP
Reactivity:
Human, Bovine, Rabbit, Sheep, Porcine
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (C-43) Antibody
Application:
IHC, IHC-P, ICC, WB, IP
Reactivity:
Human, Bovine, Rabbit, Sheep, Porcine
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
Cytokeratin 8 (KRT8, CK8) is a Type II intermediate filament chain keratin that is expressed in simple glandular epithelia and the liver. Along with KRT18, KRT8 protects the liver from stress-induced injury and apoptosis. Mutations in this gene have been linked to cryptogenic cirrhosis, rhabdoid tumors, chronic pancreatitis and liver disease. It is a component of nuclear inclusions in rhaboid tumors and Mallory bodies in liver diseases. KRT8 is positive in a variety of cancers.
References: Hepatology 2007 46(5):1639; Mod Pathol 2002 15:146; Dig Liver dis 2003 35:416; J Cell Biol 2005 171(6):931
Target
Human KRT8 / CK8 / Cytokeratin 8
Synonyms
KRT8 | CARD2 | CK-8 | CYK8 | Cytokeratin-8 | CK8 | K2C8 | K8 | KO | Keratin-8 | Type-II keratin Kb8 | Cytokeratin 8 | Keratin 8
Host
Mouse
Reactivity
Human, Bovine, Rabbit, Sheep, Porcine
(tested or 100% immunogen sequence identity)
Non-Reactivity
Mouse, Rat, Hamster, Chicken, Xenopus
Clonality
IgG1
Monoclonal
Clone
C-43
Conjugations
Unconjugated.
Also available conjugated with FITC.
Purification
Purified by protein-A affinity chromatography. Greater than 95% by SDS-PAGE.
Modifications
Unmodified
Immunogen
Cytoskeleton preparation from HeLa human cervix carcinoma cell line
Specificity
The antibody C-43 reacts with Cytokeratin 8 (52.5 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues.
Applications
- IHC
- IHC - Paraffin (20 µg/ml)
- ICC
- Western blot
- Immunoprecipitation
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.4, 15 mM Sodium Azide
Storage
Store at 2°C to 8°C. Do not freeze.
Restrictions
For research use only. Intended for use by laboratory professionals.
About KRT8 / CK8 / Cytokeratin 8
Validation
Anti-KRT8 / Cytokeratin 8 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Anti-KRT8 / Cytokeratin 8 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
See More About...
LSBio Ratings
PathPlus™ KRT8 / CK8 / Cytokeratin 8 Antibody (clone C-43) for IHC, ICC, WB/Western, IP LS-B1846 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry
Species:
Human, Monkey, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human, Mouse
Applications:
IHC - Paraffin, ICC, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/25/2024
Date Requested: 4/25/2024
