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| Catalog Number | Size | Price |
|---|---|---|
| LS-B7174-0.1 | 0.1 mg | $485 |
1 of 2
2 of 2
PathPlus™ Monoclonal Mouse anti‑Human KRT8 / CK8 / Cytokeratin 8 Antibody (clone 35‑beta‑H11, IHC, WB) LS‑B7174
PathPlus™ Monoclonal Mouse anti‑Human KRT8 / CK8 / Cytokeratin 8 Antibody (clone 35‑beta‑H11, IHC, WB) LS‑B7174
Note: This antibody replaces LS-C146755
Antibody:
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (35-beta-H11) Antibody
Application:
IHC, IHC-P, IHC-Fr, ICC, WB, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (35-beta-H11) Antibody
Application:
IHC, IHC-P, IHC-Fr, ICC, WB, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Cytokeratin 8 (KRT8, CK8) is a Type II intermediate filament chain keratin that is expressed in simple glandular epithelia and the liver. Along with KRT18, KRT8 protects the liver from stress-induced injury and apoptosis. Mutations in this gene have been linked to cryptogenic cirrhosis, rhabdoid tumors, chronic pancreatitis and liver disease. It is a component of nuclear inclusions in rhaboid tumors and Mallory bodies in liver diseases. KRT8 is positive in a variety of cancers.
References: Hepatology 2007 46(5):1639; Mod Pathol 2002 15:146; Dig Liver dis 2003 35:416; J Cell Biol 2005 171(6):931
Target
Human KRT8 / CK8 / Cytokeratin 8
Synonyms
KRT8 | CARD2 | CK-8 | CYK8 | Cytokeratin-8 | CK8 | K2C8 | K8 | KO | Keratin-8 | Type-II keratin Kb8 | Cytokeratin 8 | Keratin 8
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgM
Monoclonal
Clone
35-beta-H11
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Immunogen
Cytoskeletal preparation of the human hepotocellular carcinoma cell line Hep3B
Specificity
Reacts exlcusively with cytokeratin 8 which is present in glandular-type epithelia and most carcinomas derived thereof. It is in general not reactive in non-epithelial tissues and cells.
Applications
- IHC
- IHC - Paraffin (10 µg/ml)
- IHC - Frozen (1:100 - 1:500)
- ICC
- Western blot (1:100 - 1:1000)
- Flow Cytometry
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
For immunohistochemistry applications, this antibody is reactive on frozen tissue sections after fixation in methanol. It is particularly effective on paraffin-embedded tissues after microwave pretreatment of the slides.
Presentation
PBS, 0.09% Sodium Azide
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles. Store undiluted.
Restrictions
For research use only. Intended for use by laboratory professionals.
About KRT8 / CK8 / Cytokeratin 8
Validation
Anti-KRT8 / Cytokeratin 8 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-KRT8 / Cytokeratin 8 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
See More About...
LSBio Ratings
PathPlus™ KRT8 / CK8 / Cytokeratin 8 Antibody (clone 35-beta-H11) for IHC, ICC, WB/Western, Flow LS-B7174 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Bovine, Rabbit, Sheep, Porcine
Applications:
IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry
Species:
Human, Monkey, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/17/2024
Date Requested: 4/17/2024
