Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Monoclonal [clone SP95] (IgG) to Human KRT17 / CK17 / Cytokeratin 17
IHC - Paraffin, Western blot, Flow Cytometry
Mouse Monoclonal (IgG) to Rat KRT17 / CK17 / Cytokeratin 17
IHC - Paraffin, IHC - Frozen, Western blot
KRT17 / CK17 / Cytokeratin 17
Rat, Human (tested or 100% immunogen sequence identity)
IHC - Paraffin
IHC - Frozen
Specificity and Use
Keratin purified from rat enterocytes.
Recognizes rat keratin (MW 40kD) and human keratin 17. Reveals myoepithelial cells, basal cells and proliferating epithelia in some benign epithelial tumors. Species cross-reactivity: Human, rat. other species have not been tested.
Suitable for use in Western Blot, Immunohistochemistry on cultured cells, formalin-fixed, frozen tissue, and paraffin embedded tissue that has been fixed in ethanol. Immunohistochemistry: On cultured cells (formalin-fixed); frozen and paraffin embedded tissue that has been fixed in ethanol.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C.
May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.