Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Monoclonal [clone SP95] (IgG) to Human KRT17 / CK17 / Cytokeratin 17
IHC - Paraffin, Western blot, Flow Cytometry
Mouse Monoclonal (IgG2b,k) to Rat KRT17 / CK17 / Cytokeratin 17
IHC - Paraffin, IHC - Frozen, Immunofluorescence
KRT17 / CK17 / Cytokeratin 17
Rat, Human (tested or 100% immunogen sequence identity)
Tissue culture supernatant
IHC - Paraffin
IHC - Frozen
Specificity and Use
Keratin preparation from rat enterocytes.
Recognizes keratin 17 at 46kD. Species cross-reactivity: Human and Rat.
Suitable for use in Immunofluorescence and Immunohistochemistry. Immunohistochemistry (frozen & formalin/paraffin): 1:40-1:80 for 30 min at RT. Note: Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0 for 10-20 min., followed by cooling at RT for 20 min. Positive control: Squamous cell carcinoma or skin.
15 mM sodium azide.
Short term: +4°C; Long term: Add glycerol (40-50%) -20°C.
May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.