Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone DE-K10] (IgG1,k) to Human KRT10 / CK10 / Cytokeratin 10
IHC, Western blot
Human KRT10 / CK10 / Cytokeratin 10
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [DE-K10]
Western blot (1:50 - 1:100)
Specificity and Use
KRT10 / CK10 / Cytokeratin 10 antibody was raised against detergent insoluble extract of human epidermis.
Recognizes keratin polypeptide of 56.5 kD. It stains suprabasal cells in the epidermis, thymic Hassal's bodies. Simple and glandular epithelia, transitional epithelium and adenocarcinomas are negative with this antibody.
KRT10 / CK10 / Cytokeratin 10 encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis.