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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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KPNA1 / Importin Alpha 5 Antibody (clone 114‑E12) LS‑C16999 Best Seller
Antibody
Importin Alpha 5 antibody LS-C16999 is an unconjugated mouse monoclonal antibody to human Importin Alpha 5 (KPNA1). Validated for ELISA, IF, IP and WB.
Catalog
Size
Price
LS-C16999-100
100 µg
Unavailable

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Product Description

Importin Alpha 5 antibody LS-C16999 is an unconjugated mouse monoclonal antibody to human Importin Alpha 5 (KPNA1). Validated for ELISA, IF, IP and WB.
About KPNA1 / Importin Alpha 5
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. P52294 NM_002264 NP_002255.3

KPNA1 Antibody, Importin-alpha-S1 Antibody, Karyopherin subunit alpha-1 Antibody, NPI-1 Antibody, Importin alpha 5 Antibody, Importin subunit alpha-1 Antibody, SRP1 Antibody, SRP1-beta Antibody, RAG cohort protein 2 Antibody, Importin alpha-1 subunit Antibody, IPOA5 Antibody, Nucleoprotein interactor 1 Antibody, RCH2 Antibody


Specifications

Target
Human KPNA1 / Importin Alpha 5
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [114-E12]
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Protein A purified
Modifications
Unmodified
Applications
  • Immunofluorescence (5 - 10 µg/ml)
  • Western blot (1 - 3 µg/ml)
  • Immunoprecipitation
  • ELISA (0.1 - 1 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
GST fusion protein.
Specificity
Specific for the NPI-1 (nucleoprotein interactor-1, karyopherin alpha 1, hSRP1) protein. On Western blots, it identifies a band at ~60kD. Reactivity has been confirmed with human HeLa and MDBK cell lysates.
Usage
Suitable for use in Immunoprecipitation, Immunofluorescence, ELISA and Western Blot. Immunoprecipitation (native): 5-10 ug. Immunofluorescence: 5-10 ug/ml. ELISA: 0.1-1 ug/ml. Western Blot: 1-3 ug/ml.
Presentation
PBS, pH 7.4, 0.1% sodium azide.
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/18/2018

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