Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Western blot, Immunoprecipitation, Chromatin Immunoprecipitation, Proximity Ligation Assay
Rabbit Polyclonal to Human KMT2A / MLL
IHC - Paraffin, ELISA
Human KMT2A / MLL
Human (tested or 100% immunogen sequence identity)
Protein G purified
IHC - Paraffin (5 µg/ml)
Specificity and Use
KMT2A / MLL antibody was raised against synthetic peptide from human MLL.
Amino acids 3830 to 3845 of human MLL
Immunohistochemistry: LS-B866 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B866 was determined to be 5 ug/ml.
PBS, 0.1% sodium azide.
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
KMT2A Antibody, ALL1 Antibody, CDK6/MLL fusion protein Antibody, FLJ11783 Antibody, HRX Antibody, HTRX Antibody, HTRX1 Antibody, Lysine N-methyltransferase 2A Antibody, MLL1A Antibody, MLL/GAS7 Antibody, MLL1 Antibody, ALL-1 Antibody, MLL Antibody, MLL/GAS7 fusion protein Antibody, TRX1 Antibody, WDSTS Antibody, Trithorax-like protein Antibody, Zinc finger protein HRX Antibody, CXXC7 Antibody, MLL-AF4 der(11) fusion protein Antibody, MLL/GMPS fusion protein Antibody, TET1-MLL Antibody
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation.