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KLRB1 / CD161
killer cell lectin-like receptor subfamily B, member 1
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
| Gene Name: | killer cell lectin-like receptor subfamily B, member 1 |
| Synonyms: | KLRB1, CD161 antigen, CLEC5B, CD161, NKR-P1A, NKR, HNKR-P1A, NKR-P1, NKRP1A |
| Target Sequences: | NM_002258 NP_002249.1 Q12918 |
Publications (2)
1
IL-12, IL-15, and IL-18 pre-activated NK cells target resistant T cell acute lymphoblastic leukemia and delay leukemia development in vivo. Boieri M, Ulvmoen A, Sudworth A, Lendrem C, Collin M, Dickinson AM, Kveberg L, Inngjerdingen M. Oncoimmunology. 2017 January;6:e1274478. (Human)
[Full Text Article]
[PubMed:28405496]
[PMC:PMC5384344]
Related Antibodies: LS-C35855.
2
Immunohistochemical Evidence of the Involvement of Natural Killer (CD161+) Cells in Spontaneous Regression of Lewis Rat Sarcoma. Jana Kovalska, Monika Cervinkova, Eva Chmelikova, Daniela Planska, Jana Cizkova, Vratislav Horak. In Vivo. 2018 December;33:47-52. [Full Text Article]
[PubMed:30587601]
[PMC:PMC6364084]
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Antibodies
(61)
Proteins
(9)
Type
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(2)
Primary
(61)
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(7)
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KLRB1 / CD161
(70)
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Human
(49)
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(3)
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(13)
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(2)
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(8)
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IHC
(12)
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(8)
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(27)
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(39)
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(47)
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(5)
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(26)
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(11)
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(8)
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monoclonal mc
(47)
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(14)
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(7)
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aa73-188
(8)
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(4)
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101-150 aa, Internal
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(69)
Yes
(1)
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(2)
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(2)
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(6)
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(2)
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(2)
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Low endotoxin level
(4)
KLRB1 / CD161 Mouse anti-Human Monoclonal (Biotin) (B199.2) Antibody
Human
Flo
Biotin Conjugated
100 µg/$626
KLRB1 / CD161 Mouse anti-Human Monoclonal (B199.2) Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$562; 200 µg/$755
KLRB1 / CD161 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
Flo, IHC, IP
Biotin Conjugated
100 µl/$836
KLRB1 / CD161 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, IHC, IP
FITC Conjugated
100 µl/$836
KLRB1 / CD161 Mouse anti-Rat Monoclonal Antibody
Rat
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$572; 250 µg/$771
KLRB1 / CD161 Mouse anti-Rat Monoclonal (HRP) Antibody
Rat
Flo, IHC, IP
HRP Conjugated
100 µl/$848
KLRB1 / CD161 Mouse anti-Rat Monoclonal (Biotin) Antibody
Rat
Flo, IHC, IP
Biotin Conjugated
100 µl/$848
KLRB1 / CD161 Mouse anti-Rat Monoclonal (PE) Antibody
Rat
Flo, IHC, IP
PE Conjugated
100 Tests/$794
KLRB1 / CD161 Mouse anti-Rat Monoclonal (10/78) Antibody
Rat
Flo, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$395
KLRB1 / CD161 Mouse anti-Human Monoclonal (aa67-225) (OTI1D8) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
KLRB1 / CD161 Mouse anti-Human Monoclonal (aa67-225) (Carrier-free) (OTI1D8) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
KLRB1 / CD161 Mouse anti-Rat Monoclonal (Preservative Free) (10/78) Antibody
Rat
Flo, IHC-Fr, IP, RIA, WB
Unconjugated, Preservative Free
1 mg/$712
KLRB1 / CD161 Mouse anti-Human Monoclonal (B199.2) Antibody
Human
Flo, IHC-Fr, IP
Unconjugated
0.1 mg/$385
KLRB1 / CD161 Mouse anti-Human Monoclonal (aa68-225) (14F1F11) Antibody
Human
WB
Unconjugated
0.1 mg/$386
KLRB1 / CD161 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
KLRB1 / CD161 Mouse anti-Human Monoclonal (4C6A11) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
KLRB1 / CD161 Mouse anti-Rat Monoclonal (10/78) Antibody
Rat
Flo, IHC-Fr, IP, RIA, WB
Unconjugated
0.1 mg/$281
KLRB1 / CD161 Mouse anti-Rat Monoclonal (FITC) (10/78) Antibody
Rat
Flo, IHC-Fr, IP, RIA, WB
FITC Conjugated
0.1 mg/$323
KLRB1 / CD161 Mouse anti-Rat Monoclonal (PE) (10/78) Antibody
Rat
Flo, IHC-Fr, IP, RIA, WB
PE Conjugated
0.1 mg/$337
KLRB1 / CD161 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
KLRB1 / CD161 Mouse anti-Human Monoclonal (HP-3G10) Antibody
Human, Non-Human Primates
Flo, WB
Unconjugated
0.1 mg/$302
KLRB1 / CD161 Mouse anti-Human Monoclonal (PE) (HP-3G10) Antibody
Human, Non-Human Primates
Flo, WB
PE Conjugated
100 Tests/$365
KLRB1 / CD161 Mouse anti-Human Monoclonal (2F3) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
KLRB1 / CD161 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
KLRB1 / CD161 Rabbit anti-Human Polyclonal (101-150 aa, Internal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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