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Anti-KLKB1 / Plasma Kallikrein Antibody (clone 13G11) LS-C83337

Ordering

Wt. Vol. Conc. Price
200 µg - - $475
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
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866-206-6909
Orders@LSBio.com
 

Most Popular KLKB1 / Plasma Kallikrein Antibodies

Anti-KLKB1 / Plasma Kallikrein Antibody (clone 13G11) LS-C38308
Mouse Monoclonal [clone 13G11] (IgG1) to Human KLKB1 / Plasma Kallikrein
Human
Western blot, ELISA
Unconjugated
Anti-KLKB1 / Plasma Kallikrein Antibody IHC-plus™ LS-B2772
Sheep Polyclonal (IgG) to Human KLKB1 / Plasma Kallikrein
Human
IHC - Paraffin, ELISA, Immunoelectrophoresis
Unconjugated
Immunohistochemistry Image
Anti-KLKB1 / Plasma Kallikrein Antibody (aa507-537, Azide-free, HRP) LS-C261492
Rabbit Polyclonal (IgG) to Human KLKB1 / Plasma Kallikrein
Human
Western blot, ELISA
HRP Conjugated, Azide-free

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 13G11] (IgG1) to Human KLKB1 / Plasma Kallikrein
Human
Western blot, ELISA
Unconjugated

Details

Human KLKB1 / Plasma Kallikrein
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [13G11]
Unconjugated
Protein G purified
Unmodified

Applications

  • Western blot
  • ELISA

Specificity and Use

KLKB1 / Plasma Kallikrein antibody was raised against human plasma prekallikrein.
Specifically recognizes in human plasma two variants (88 kD and 85 kD) of prekallikrein and its activation products kallikrein (88 kD and 85 kD), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and antithrombin III, and 45 kD prekallikrein/kallikrein fragment(s). It also recognizes prekallikrein and its activation products in chimpanzee, rhesus, and baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in human and rhesus plasmas by approximately 60-80% and 55%, respectively. Does not cross-react with tissue kallikrein.
May be used in ELISA and Western blots to identify/quantitate prekallikrein and its activation products in plasmas of humans, chimpanzees, rhesus monkeys, and baboons. NOTE: Prekallikrein activation may occur with repeated freezing/thawing (3x or more) of plasma samples obtained from humans or other primates.

Packaging

PBS, pH 7.4
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About KLKB1 / Plasma Kallikrein

P03952 NM_000892 NP_000883.2

KLKB1 Antibody, Fletcher factor deficiency Antibody, Fletcher factor Antibody, Kininogenin Antibody, Plasma kallikrein Antibody, PKK deficiency Antibody, Plasma kallikrein heavy chain Antibody, PPK Antibody, Prekallikrein deficiency Antibody, Plasma kallikrein light chain Antibody, Plasma prekallikrein Antibody, Kallikrein 3 Antibody

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond.

Requested From: United States
Date Requested: 12/2/2016

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