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KLF4

Kruppel-like factor 4 (gut)

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Gene Name: Kruppel-like factor 4 (gut)
Synonyms: KLF4, EZF, GKLF, Kruppel-like factor 4 (gut), Hezf, Krueppel-like factor 4
Target Sequences: NM_004235 NP_004226.3 O43474

Publications (2)

1
Caveolin-3 Promotes a Vascular Smooth Muscle Contractile Phenotype. Gutierrez-Pajares JL, Iturrieta J, Dulam V, Wang Y, Pavlides S, Malacari G, Lisanti MP, Frank PG. Frontiers in cardiovascular medicine. 2015 2:27. (WB; Human) [Full Text Article] [PubMed:26664898] [PMC:PMC4671348] Related Antibodies: LS-B5641.
2
Immunohistochemical analysis of monocytic leukemias: usefulness of CD14 and Kruppel-like factor 4, a novel monocyte marker. Klco JM, Kulkarni S, Kreisel FH, Nguyen TD, Hassan A, Frater JL. American journal of clinical pathology. 2011 135:720-30. (IHC; Human) [Full Text Article] [PubMed:21502426] Related Antibodies: LS-B1192.

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Antibodies (86)
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KLF4 Antibody - Anti-KLF4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KLF4 Rabbit anti-Human Polyclonal (aa401-450) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
KLF4 Antibody - Anti-KLF4 antibody IHC of human melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KLF4 Rabbit anti-Human Polyclonal (aa80-129) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
KLF4 Antibody - Anti-KLF4 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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KLF4 Mouse anti-Human Monoclonal (aa1-170) (AT4E6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
KLF4 Antibody - Immunofluorescence of KLF4 antibody (5 ug/ml). HeLa cells transfected with pMX constructs of human KLF4 (top) and NIH3T3 cells transfected with pMX constructs of mouse KLF4 (bottom) were analyzed at approximately 62 hours after transfection.
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KLF4 Mouse anti-Human Monoclonal (56CT5.1.6) Antibody
Mouse, Human
Flo, IF, WB
Unconjugated
200 µl/$393
KLF4 Antibody - Formalin-fixed and paraffin-embedded human prostate carcinoma tissue reacted with KLF4 antibody (N-term C74) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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KLF4 Rabbit anti-Human Polyclonal (aa69-101) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
KLF4 Protein
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E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
KLF4 Antibody - Antibody (0.1 ug/ml) staining of Human Duodenum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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KLF4 Goat anti-Human Polyclonal (aa11-22) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
KLF4 Antibody - IHC of paraffin-embedded colon cancer tissues (left) and lung cancer tissues (right) using KLF4 mouse monoclonal antibody with DAB staining
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KLF4 Mouse anti-Human Monoclonal (1E6) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$435
KLF4 Antibody - Fluorescent confocal image of SY5Y cells stained KLF4 antibody. SY5Y cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min), then incubated KLF4 primary antibody (1:200, 2 h at room temperature). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (5.25 mu M, 25 min). KLF4 immunoreactivity is localized very specifically to the nuclei of the SY5Y cells.
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KLF4 Rabbit anti-Human Polyclonal (aa394-421) Antibody
Human
Flo, ICC, IF, WB
Unconjugated
400 µl/$393
KLF4 Antibody - WB of KLF4 antibody. Lane 1: HELA Cell Lysate. Lane 2: A549 Cell Lysate. Lane 3: U20S Cell Lysate.
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KLF4 Rabbit anti-Human Polyclonal (aa93-108) Antibody
Mouse, Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
KLF4 Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
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KLF4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
KLF4 Antibody - Immunohistochemistry of KLF4 in rat liver tissue with KLF4 antibody at 5 ug/ml.
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KLF4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
0.1 mg/$460
KLF4 Antibody - IHC analysis of KLF4 using anti-KLF4 antibody. KLF4 was detected in paraffin-embedded section of rat small intestine tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2?g/ml rabbit anti-KLF4 Antibody overnight at 4?C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37?C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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KLF4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
KLF4 Antibody - KLF4 Antibody in Immunohistochemistry (IHC)
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KLF4 Mouse anti-Human Monoclonal (1000000) Antibody
Human
ICC, IF, IHC, WB
Unconjugated
100 µl/$541
KLF4 Antibody - KLF4 antibody Western blot of Mouse Kidney lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KLF4 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
KLF4 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded colon cancer tissues (left) and Lung Cancer Tissues (right) with DAB staining using GKLF Monoclonal Antibody.
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KLF4 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
KLF4 Antibody - Formalin-fixed and paraffin-embedded human colon carcinoma with KLF4 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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KLF4 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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KLF4 Mouse anti-Human Monoclonal (56CT5.1.6) Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
200 µl/$734
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KLF4 Mouse anti-Human Monoclonal (Biotin) (56CT5.1.6) Antibody
Human
ELISA, Flo, ICC, IF, WB
Biotin Conjugated
200 µl/$952
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KLF4 Mouse anti-Human Monoclonal (FITC) (56CT5.1.6) Antibody
Human
ELISA, Flo, ICC, IF, WB
FITC Conjugated
200 µl/$952
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KLF4 Mouse anti-Human Monoclonal (APC) (56CT5.1.6) Antibody
Human
ELISA, Flo, ICC, IF, WB
APC Conjugated
200 µl/$952
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KLF4 Mouse anti-Human Monoclonal (Azide-free) (HRP) (56CT5.1.6) Antibody
Human
ELISA, Flo, ICC, IF, WB
HRP Conjugated, Azide-free
200 µl/$952
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KLF4 Mouse anti-Human Monoclonal (PE) (56CT5.1.6) Antibody
Human
ELISA, Flo, ICC, IF, WB
PE Conjugated
200 µl/$952
KLF4 Antibody - Western blot of recombinant KLF4.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KLF4 Rabbit anti-Mouse Polyclonal (aa240-478) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$345; 200 µl/$402; 500 µl/$594; 1 ml/$737; 2 ml/$976; 5 ml/$1,676
KLF4 Antibody - Western blot of recombinant KLF4.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KLF4 Rabbit anti-Mouse Polyclonal (aa240-478) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
Viewing 1-25 of 102 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).