Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 2F9] (IgG2a) to Human KIR2DL1 / CD158a
Western blot, Immunoprecipitation, ELISA
Human KIR2DL1 / CD158a
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [2F9]
Protein G purified
IHC - Paraffin
Specificity and Use
KIR2DL1 / CD158a antibody was raised against recombinant human KIR2DL1 (23-223 aa) purified from E. coli.
The antibody has been tested by ELISA and immunoprecipitation analysis to assure specificity and reactivity. Since application varies, however, each investigation should titrate the reagent to obtain optimal results.
PBS, pH 7.4, 0.1% sodium azide
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
KIR2DL1 Antibody, 47.11 Antibody, Cl-42 Antibody, MHC class I NK cell receptor Antibody, NKAT-1 Antibody, p58 NK receptor CL-42/47.11 Antibody, NKAT Antibody, NKAT1 Antibody, p58.1 Antibody, CD158A Antibody, CD158a antigen Antibody, Killer Ig receptor Antibody, KIR-K64 Antibody, KIR221 Antibody
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2).
Recombinant human protein KIR2DL1, KIR2DL3, KIR2DS4 and KIR2DL4 (each 50 ng per well) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human KIR2DL1 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1: KIR2DL1; Lane 2: KIR2DL3; Lane 3: KIR2DS4; Lane 4: KIR2DL4.