Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse, Human (tested or 100% immunogen sequence identity)
Specificity and Use
KDR / VEGFR2 / FLK1 antibody was raised against a synthetic peptide made to an internal region of the murine VEGFR2 protein sequence (between residues 1200-1300).
Specific for VEGR-2. Species cross-reactivity: This antibody reacts with the human protein. Other species have not yet been tested. The immunogen used for this antibody production has 100% homology with mouse, rat and human proteins.
Suitable for use in Western Blot. Positive control: HUVEC lysate.
Tris-glycine, 150 mM sodium chloride, pH 7.2
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD.