Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
KDR / VEGFR2 / FLK1 antibody was raised against a synthetic peptide made to an internal region of the murine VEGFR2 protein sequence (between residues 1200-1300) Percent identity by BLAST analysis: Mouse, Rat, Human (100%).
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD.
Detection of VEGFR-2 doublet in VEGFR-2 induced HUVEC lysate (50 ug) using LS-C2933 (4 ug/ml). ECL detection 2.5 minutes. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of VEGFR-2 doublet in CSF-1 receptor/VEGFR2 chimera transfected lysate (20 ug) using LS-C2933 (6 ug/ml). ECL detection 30 seconds. This image was taken for the unconjugated form of this product. Other forms have not been tested.