KDM1A / LSD1

lysine (K)-specific demethylase 1A

Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.

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Products

Antibodies (38)

Proteins (6)

ELISA Kits (3)

Type

Over-Expression Lysate (4)

Primary (38)

Recombinant (2)

Sandwich (3)

Target

KDM1A / LSD1 (47)

Reactivity

Human (40)

Mouse (18)

Rat (14)

Bovine (1)

Dog (2)

Macaque (1)

Monkey (4)

Non-Human Primate (1)

Pig (1)

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Application

IHC (21)

IHC-P (11)

WB (30)

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ChIP-Seq (2)

ELISA (16)

ICC (2)

IF (14)

IP (5)

Peptide-ELISA (2)

Host

rabbit (23)

mouse (14)

goat (1)

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IHCPlus (4)

Isotype

IgG (19)

IgG1 (8)

IgG2a,k (1)

Clonality

monoclonal mc (13)

polyclonal pc (25)

Clone

1B2E5 (2)

1B2F2 (1)

2E7 (1)

3F9A3 (1)

3F9D2 (1)

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96-Well Strip Plate (3)

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FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (35)

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aa50-100 (2)

C-Terminus (1)

Internal (1)

Internal Region (1)

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aa100-150 (1)

aa108-142 (1)

aa457-490 (1)

aa819-852 (1)

aa825-C-term (1)

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Myc-DDK (Flag) (5)

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Human (4)

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HEK 293 Cells (3)

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Purified (1)

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IHC-plus™ KDM1A / LSD1 Antibody (aa100-150) LS-B2014

(4.0) Rating

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal (aa100-150) Antibody

Reactivity:

Zebrafish, Rat, Mouse, Dog, Human, Monkey, Macaque

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$440

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IHC-plus™ KDM1A / LSD1 Antibody (clone 2E7) LS-B6214

(4.0) Rating

Antibody:

KDM1A / LSD1 Mouse anti-Human Monoclonal (2E7) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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KDM1A / LSD1 Antibody (C-Terminus) LS-C37229

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, Flo, ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$688

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KDM1A / LSD1 Antibody LS-C331306

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ChIP-Seq, IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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KDM1A / LSD1 Antibody (aa819-852) LS-C98760

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal (aa819-852) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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IHC-plus™ KDM1A / LSD1 Antibody LS-B3800

(4.0) Rating

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

Select

IHC-plus™ KDM1A / LSD1 Antibody LS-B3799

(4.0) Rating

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

Select

KDM1A / LSD1 Antibody (clone 3F9D2) LS-C669478

Antibody:

KDM1A / LSD1 Mouse anti-Human Monoclonal (3F9D2) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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KDM1A / LSD1 Antibody (clone 3F9A3) LS-C669486

Antibody:

KDM1A / LSD1 Mouse anti-Human Monoclonal (3F9A3) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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KDM1A / LSD1 Antibody LS-C678411

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

KDM1A / LSD1 Antibody (aa108-142) LS-C98758

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal (aa108-142) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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KDM1A / LSD1 Antibody LS-C833579

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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KDM1A / LSD1 Antibody LS-C813042

Antibody:

KDM1A / LSD1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Dog, Bovine, Pig, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$406; 200 µg/$505

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KDM1A / LSD1 Antibody (aa50-100) LS-C761980

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal (aa50-100) Antibody

Reactivity:

Human

Applications:

ChIP-Seq, IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

KDM1A / LSD1 Antibody LS-C394102

Antibody:

KDM1A / LSD1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$391

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KDM1A / LSD1 Antibody (clone 1B2E5) LS-C47158

Antibody:

KDM1A / LSD1 Mouse anti-Human Monoclonal (1B2E5) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$380

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KDM1A / LSD1 Antibody (clone GF1) LS-C190302

Antibody:

KDM1A / LSD1 Mouse anti-Human Monoclonal (GF1) Antibody

Reactivity:

Human

Applications:

ELISA, IF

Format:

Unconjugated

Price:

100 µl/$688

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KDM1A / LSD1 Antibody (aa825-C-term) LS-C287135

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal (aa825-C-term) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

KDM1A / LSD1 Antibody (clone 5B2D5) LS-C669476

Antibody:

KDM1A / LSD1 Mouse anti-Human Monoclonal (5B2D5) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µl/$459

Select

KDM1A / LSD1 Antibody LS-C813026

Antibody:

KDM1A / LSD1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human, Monkey

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

Select

KDM1A / LSD1 Antibody (aa457-490) LS-C98759

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal (aa457-490) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

KDM1A / LSD1 Antibody LS-C806081

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

KDM1A / LSD1 Antibody (clone 1B2E5) LS-C758488

Antibody:

KDM1A / LSD1 Mouse anti-Human Monoclonal (1B2E5) Antibody

Reactivity:

Mouse, Human, Non-Human Primate

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$518

Select

KDM1A / LSD1 Antibody LS-C37228

Antibody:

KDM1A / LSD1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$665

Select

KDM1A / LSD1 Antibody LS-C192409

Antibody:

KDM1A / LSD1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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